WARS2

WARS2
Identifiers
Aliases	WARS2, TrpRS, tryptophanyl tRNA synthetase 2, mitochondrial
External IDs	MGI: 1917810 HomoloGene: 5673 GeneCards: WARS2
Gene ontology Molecular function • aminoacyl-tRNA ligase activity • nucleotide binding • ligase activity • ATP binding • tryptophan-tRNA ligase activity Cellular component • cytoplasm • mitochondrial matrix • mitochondrion Biological process • vasculogenesis • tryptophanyl-tRNA aminoacylation • tRNA aminoacylation for protein translation • translation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10352	70560
Ensembl	ENSG00000116874	ENSMUSG00000004233
UniProt	Q9UGM6	Q9CYK1
RefSeq (mRNA)	NM_015836 NM_201263	NM_027462
RefSeq (protein)	NP_056651.1 NP_957715.1	NP_081738.2
Location (UCSC)	Chr 1: 119.03 – 119.14 Mb	Chr 3: 99.14 – 99.24 Mb
PubMed search	[1]	[2]
Wikidata

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Tryptophanyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the WARS2 gene.^[3][4][5]

Function

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Martinez-Dominguez MT, Justesen J, Kruse TA, Hansen LL (Mar 1999). "Assignment of the human mitochondrial tryptophanyl-tRNA synthetase (WARS2) to 1p13.3→p13.1 by radiation hybrid mapping". Cytogenet Cell Genet. 83 (3–4): 249–50. doi:10.1159/000015196. PMID 10072595.
4. Jorgensen R, Søgaard TM, Rossing AB, Martensen PM, Justesen J (Jul 2000). "Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase". J Biol Chem. 275 (22): 16820–6. doi:10.1074/jbc.275.22.16820. PMID 10828066.
5. "Entrez Gene: WARS2 tryptophanyl tRNA synthetase 2, mitochondrial".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Liu J, Shue E, Ewalt KL, Schimmel P (2004). "A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase". Nucleic Acids Res. 32 (2): 719–27. doi:10.1093/nar/gkh240. PMC 373357. PMID 14757836.
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
• Guo LT, Chen XL, Zhao BT, Shi Y, Li W, Xue H, Jin YX (2007). "Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311". Nucleic Acids Res. 35 (17): 5934–43. doi:10.1093/nar/gkm633. PMC 2034488. PMID 17726052.

External links

• WARS2 human gene location in the UCSC Genome Browser.
• WARS2 human gene details in the UCSC Genome Browser.