ZFPM1

ZFPM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XU7
Identifiers
Aliases	ZFPM1, FOG, FOG1, ZC2HC11A, ZNF408, ZNF89A, zinc finger protein, FOG family member 1
External IDs	MGI: 1095400 HomoloGene: 7606 GeneCards: ZFPM1
Gene ontology Molecular function • DNA binding • RNA polymerase II transcription factor binding • transcription factor binding • metal ion binding • RNA polymerase II activating transcription factor binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • nucleic acid binding • RNA polymerase II core promoter sequence-specific DNA binding Cellular component • cytoplasm • transcription factor complex • transcriptional repressor complex • nucleoplasm • nucleus Biological process • megakaryocyte development • megakaryocyte differentiation • negative regulation of mast cell differentiation • negative regulation of interleukin-4 biosynthetic process • negative regulation of fat cell differentiation • regulation of transcription, DNA-templated • homeostasis of number of cells • transcriptional activation by promoter-enhancer looping • positive regulation of interferon-gamma biosynthetic process • ventricular septum morphogenesis • outflow tract morphogenesis • platelet formation • blood coagulation • cardiac muscle tissue morphogenesis • negative regulation of transcription from RNA polymerase II promoter • negative regulation of protein binding • transcription, DNA-templated • regulation of chemokine production • atrial septum morphogenesis • heart development • atrioventricular valve morphogenesis • granulocyte differentiation • embryonic hemopoiesis • regulation of definitive erythrocyte differentiation • T-helper cell lineage commitment • primitive erythrocyte differentiation • mitral valve formation • tricuspid valve formation • definitive erythrocyte differentiation • positive regulation of transcription from RNA polymerase II promoter • erythrocyte differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	161882	22761
Ensembl	ENSG00000179588	ENSMUSG00000049577
UniProt	Q8IX07	O35615
RefSeq (mRNA)	NM_153813	NM_009569
RefSeq (protein)	NP_722520.2	NP_033595.1
Location (UCSC)	Chr 16: 88.45 – 88.54 Mb	Chr 8: 122.28 – 122.34 Mb
PubMed search	[1]	[2]
Wikidata

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Zinc finger protein ZFPM1 also known as friend of GATA protein 1 (FOG1) is a protein that in humans is encoded by the ZFPM1 gene.^[3] It is a cofactor of the GATA1 transcription factor.

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: ZFPM1 zinc finger protein, multitype 1".

Further reading

• Tsang AP, Visvader JE, Turner CA, et al. (1997). "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation.". Cell. 90 (1): 109–19. doi:10.1016/S0092-8674(00)80318-9. PMID 9230307.
• Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators.". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMC 1170841. PMID 9724649.
• Mehaffey MG, Newton AL, Gandhi MJ, et al. (2001). "X-linked thrombocytopenia caused by a novel mutation of GATA-1.". Blood. 98 (9): 2681–8. doi:10.1182/blood.V98.9.2681. PMID 11675338.
• Yu C, Niakan KK, Matsushita M, et al. (2002). "X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction.". Blood. 100 (6): 2040–5. doi:10.1182/blood-2002-02-0387. PMC 2808424. PMID 12200364.
• Freson K, Thys C, Wittewrongel C, et al. (2003). "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions.". Hum. Genet. 112 (1): 42–9. doi:10.1007/s00439-002-0832-1. PMID 12483298.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Liew CK, Simpson RJ, Kwan AH, et al. (2005). "Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction.". Proc. Natl. Acad. Sci. U.S.A. 102 (3): 583–8. doi:10.1073/pnas.0407511102. PMC 545545. PMID 15644435.
• Vannucchi AM, Pancrazzi A, Guglielmelli P, et al. (2005). "Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis.". Am. J. Pathol. 167 (3): 849–58. doi:10.1016/S0002-9440(10)62056-1. PMC 1698737. PMID 16127162.
• Yang HY, Kim SH, Kim SH, et al. (2007). "The suppression of zfpm-1 accelerates the erythropoietic differentiation of human CD34+ cells". Biochem. Biophys. Res. Commun. 353 (4): 978–84. doi:10.1016/j.bbrc.2006.12.155. PMID 17207461.