Zinc finger FYVE domain-containing protein 9

ZFYVE9
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1DEV, 1MK2, 4BKW
Identifiers
Aliases	ZFYVE9, MADHIP, NSP, PPP1R173, SARA, SMADIP, zinc finger FYVE-type containing 9
External IDs	MGI: 2652838 HomoloGene: 3527 GeneCards: ZFYVE9
Gene ontology Molecular function • 1-phosphatidylinositol binding • serine-type peptidase activity • protein binding • metal ion binding Cellular component • cytoplasm • endosome • early endosome • early endosome membrane • membrane Biological process • SMAD protein complex assembly • endocytosis • transforming growth factor beta receptor signaling pathway • SMAD protein import into nucleus • proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9372	230597
Ensembl	ENSG00000157077	ENSMUSG00000034557
UniProt	O95405	n/a
RefSeq (mRNA)	NM_004799 NM_007323 NM_007324	NM_183300
RefSeq (protein)	NP_004790.2 NP_015563.2	n/a
Location (UCSC)	Chr 1: 52.14 – 52.35 Mb	Chr 4: 108.64 – 108.78 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Zinc finger FYVE domain-containing protein 9 or SARA (SMAD anchor for receptor activation) is a protein that in humans is encoded by the ZFYVE9 gene.^[3] SARA contains a double zinc finger (FYVE domain).

SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors.^[4] It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates form SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL (December 1998). "SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor". Cell. 95 (6): 779–791. doi:10.1016/S0092-8674(00)81701-8. PMID 9865696.
4. Lin HK, Bergmann S, Pandolfi PP (September 2004). "Cytoplasmic PML function in TGF-beta signalling". Nature. 431 (7005): 205–211. doi:10.1038/nature02783. PMID 15356634.