Adrenodoxin-NADP+ reductase

Adrenodoxin-NADP^+ reductase
Identifiers
EC number	1.18.1.6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Adrenodoxin-NADP⁺ reductase (EC 1.18.1.6, adrenodoxin reductase, nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase, ADR, NADPH:adrenal ferredoxin oxidoreductase) is an enzyme with systematic name adrendoxin:NADP⁺ oxidoreductase.^{[1][2][3][4][5][6][7]} This enzyme catalyses the following chemical reaction

2 reduced adrenodoxin + NADP⁺ $\rightleftharpoons$ 2 oxidized adrenodoxin + NADPH + H⁺

Adrenodoxin-NADP+ reductase is a flavoprotein (FAD).

References

1. Omura, T.; Sanders, E.; Estabrook, R.W.; Cooper, D.Y.; Rosenthal, O. (1966). "Isolation from adrenal cortex of a nonheme iron protein and a flavoprotein functional as a reduced triphosphopyridine nucleotide-cytochrome P-450 reductase". Arch. Biochem. Biophys. 117: 660–673. doi:10.1016/0003-9861(66)90108-1.
2. Chu, J.W.; Kimura, T. (1973). "Studies on adrenal steroid hydroxylases. Molecular and catalytic properties of adrenodoxin reductase (a flavoprotein)". J. Biol. Chem. 248 (6): 2089–2094. PMID 4144106.
3. Sugiyama, T.; Yamano, T. (1975). "Purification and crystallization of NADPH-adrenodoxin reductase from bovine adrenocortical mitochondria". FEBS Lett. 52 (1): 145–148. doi:10.1016/0014-5793(75)80658-2. PMID 235468.
4. Hanukoglu, I.; Jefcoate, C.R. (1980). "Mitochondrial cytochrome P-450_sec. Mechanism of electron transport by adrenodoxin". J. Biol. Chem. 255 (7): 3057–3061. PMID 6766943.
5. Hanukoglu, I.; Hanukoglu, Z. (1986). "Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum. Implications for membrane organization and gene regulation". Eur. J. Biochem. 157: 27–31. doi:10.1111/j.1432-1033.1986.tb09633.x. PMID 3011431.
6. Hanukoglu, I.; Gutfinger, T. (1989). "cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases". Eur. J. Biochem. 180: 479–484. doi:10.1111/j.1432-1033.1989.tb14671.x. PMID 2924777.
7. Ziegler, G.A.; Vonrhein, C.; Hanukoglu, I.; Schulz, G.E. (1999). "The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis". J. Mol. Biol. 289: 981–990. doi:10.1006/jmbi.1999.2807. PMID 10369776.

External links

• Adrenodoxin-NADP reductase at the US National Library of Medicine Medical Subject Headings (MeSH)