CEP170

CEP170
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JON
Identifiers
Aliases	CEP170, FAM68A, KAB, KIAA0470, centrosomal protein 170
External IDs	MGI: 1918348 HomoloGene: 22844 GeneCards: CEP170
Orthologs
Species	Human	Mouse
Entrez	9859	545389
Ensembl	n/a	ENSMUSG00000057335
UniProt	Q5SW79	Q6A065
RefSeq (mRNA)	NM_001042404 NM_001042405 NM_014812	NM_001024722 NM_001099637
RefSeq (protein)	NP_001035863.1 NP_001035864.1 NP_055627.2	XP_006497000.1 XP_006497001.1
Location (UCSC)	Chr 1: 243.12 – 243.26 Mb	Chr 1: 176.73 – 176.81 Mb
PubMed search	[1]	[2]
Wikidata

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Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.^[3][4]

Function

The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with the intraflagellar transport protein 81 (IFT81), the SH3-domain containing protein PRAX-1, and is phosphorylated by cyclin dependent kinase 1 ( Cdk1 ) and polo-like kinase 1 ( PLK1 ), and functions in maintaining Microtubule organization, cell morphology and cilium stability.^[3]

The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: CEP170 centrosomal protein 170kDa".
4. Guarguaglini G, Duncan PI, Stierhof YD, Holmström T, Duensing S, Nigg EA (March 2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles". Molecular Biology of the Cell. 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC 551476. PMID 15616186.

Further reading

• Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling.". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Guarguaglini G, Duncan PI, Stierhof YD, et al. (2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles.". Mol. Biol. Cell. 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC 551476. PMID 15616186.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Lamla S (2009). "Functional characterisation of the centrosomal protein Cep170.". Dissertation, LMU Muenchen: Fakultät für Biologie. URN nbn:de:bvb:19-97838.