Furethidine

Furethidine

Clinical data
ATC code	none
Legal status
Legal status	AU: S9 (Prohibited) CA: Schedule I DE: Anlage I (Controlled) UK: Class A US: Schedule I
Identifiers
IUPAC name ethyl 1-[2-(oxolan-2-ylmethoxy)ethyl]-4-phenylpiperidine-4-carboxylate
Synonyms	ethyl 4-phenyl-1-(2-tetrahydrofurfuryloxyethyl)piperidine-4-carboxylate
CAS Number	2385-81-1
PubChem (CID)	61306
DrugBank	DB01464
ChemSpider	55245
UNII	6U9XA4JOD4
ChEMBL	CHEMBL2105078
ECHA InfoCard	100.017.451
Chemical and physical data
Formula	C21H31NO4
Molar mass	361.48 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(OCC)C3(c1ccccc1)CCN(CCOCC2OCCC2)CC3
InChI InChI=1S/C21H31NO4/c1-2-25-20(23)21(18-7-4-3-5-8-18)10-12-22(13-11-21)14-16-24-17-19-9-6-15-26-19/h3-5,7-8,19H,2,6,9-17H2,1H3 Key:NNCOZXNZFLUYGG-UHFFFAOYSA-N
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Furethidine is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine (meperidine).^[1]

Furethidine is not currently used in medicine and is a Class A/Schedule I drug which is controlled under UN drug conventions. It has similar effects to other opioid derivatives, such as analgesia, sedation, nausea and respiratory depression.^[2] In the United States it is a Schedule I Narcotic controlled substance with the ACSCN of 9626.^[3]

References

1. Maul C, Buschmann H, Sundermann B. Opioids: 3.3 Synthetic Opioids. Analgesics 2005; 159-169. ISBN 978-3-527-30403-5
2. Cahal DA, Dare JG, Keith D. A Sequential Trial of Analgesics in Labour. International Journal of Obstetrics and Gynaecology 1961; 68(1): 88–93.
3. http://www.deadiversion.usdoj.gov/schedules/orangebook/d_cs_drugcode.pdf, pp. 13, accessed 23. January 2016

• UNODC Bulletin on Narcotics 1961