GLRA2

GLRA2
Identifiers
Aliases	GLRA2, GLR, glycine receptor alpha 2
External IDs	MGI: 95748 HomoloGene: 31070 GeneCards: GLRA2
Targeted by Drug
dronabinol, 5,7-dichlorokynurenic acid, bilobalide, hu-210, pregnenolone sulfate, win 55212-2, picrotoxin[1]
Gene ontology Molecular function • metal ion binding • glycine binding • transmitter-gated ion channel activity • chloride channel activity • glycine-gated chloride ion channel activity • extracellular-glycine-gated chloride channel activity • extracellular ligand-gated ion channel activity Cellular component • synapse • integral component of membrane • cell projection • cell junction • integral component of plasma membrane • postsynaptic membrane • membrane • chloride channel complex • plasma membrane Biological process • neuropeptide signaling pathway • chloride transmembrane transport • chloride transport • ion transport • transport • cellular response to amino acid stimulus • synaptic transmission, glycinergic • cellular response to ethanol • cellular response to zinc ion • ion transmembrane transport • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2742	237213
Ensembl	ENSG00000101958	ENSMUSG00000018589
UniProt	P23416	Q7TNC8
RefSeq (mRNA)	NM_001118885 NM_001118886 NM_001171942 NM_002063	NM_183427
RefSeq (protein)	NP_001112357.1 NP_001112358.1 NP_001165413.1 NP_002054.1	NP_906272.1
Location (UCSC)	Chr X: 14.53 – 14.73 Mb	Chr X: 165.13 – 165.33 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Glycine receptor subunit alpha-2 is a protein that in humans is encoded by the GLRA2 gene.^[4]

See also

• Glycine receptor

References

1. "Drugs that physically interact with Glycine receptor subunit alpha-2 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. "Entrez Gene: GLRA2 glycine receptor, alpha 2".

Further reading

• Grenningloh G, Schmieden V, Schofield PR, et al. (1990). "Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes.". EMBO J. 9 (3): 771–6. PMC 551735. PMID 2155780.
• Monani U, Burghes AH (1997). "Structure of the human alpha 2 subunit gene of the glycine receptor--use of vectorette and Alu-exon PCR.". Genome Res. 6 (12): 1200–6. doi:10.1101/gr.6.12.1200. PMID 8973915.
• Cummings CJ, Dahle EJ, Zoghbi HY (1998). "Analysis of the genomic structure of the human glycine receptor alpha2 subunit gene and exclusion of this gene as a candidate for Rett syndrome.". Am. J. Med. Genet. 78 (2): 176–8. doi:10.1002/(SICI)1096-8628(19980630)78:2<176::AID-AJMG16>3.0.CO;2-K. PMID 9674912.
• Feng J, Craddock N, Jones IR, et al. (2001). "Systematic screening for mutations in the glycine receptor alpha2 subunit gene (GLRA2) in patients with schizophrenia and other psychiatric diseases.". Psychiatr. Genet. 11 (1): 45–8. doi:10.1097/00041444-200103000-00009. PMID 11409700.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Davies DL, Crawford DK, Trudell JR, et al. (2004). "Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism.". J. Neurochem. 89 (5): 1175–85. doi:10.1111/j.1471-4159.2004.02390.x. PMID 15147510.
• Miller PS, Harvey RJ, Smart TG (2005). "Differential agonist sensitivity of glycine receptor alpha2 subunit splice variants.". Br. J. Pharmacol. 143 (1): 19–26. doi:10.1038/sj.bjp.0705875. PMC 1575261. PMID 15302677.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Miller PS, Da Silva HM, Smart TG (2006). "Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors.". J. Biol. Chem. 280 (45): 37877–84. doi:10.1074/jbc.M508303200. PMID 16144831.

External links

• GLRA2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.