Zinc-activated ion channel

ZACN
Identifiers
Aliases	ZACN, L2, LGICZ, LGICZ1, ZAC, ZAC1, Zinc-activated ion channel, zinc activated ion channel
External IDs	HomoloGene: 52296 GeneCards: ZACN
Targeted by Drug
tubocurarine, Hydron[1]
Gene ontology Molecular function • extracellular ligand-gated ion channel activity • acetylcholine binding • zinc ion binding • acetylcholine receptor activity • acetylcholine-activated cation-selective channel activity • G-protein coupled serotonin receptor activity • ligand-gated ion channel activity • serotonin-activated cation-selective channel activity Cellular component • integral component of membrane • acetylcholine-gated channel complex • plasma membrane • membrane Biological process • transport • ion transmembrane transport • response to zinc ion • synaptic transmission, cholinergic • ion transport • serotonin receptor signaling pathway • cation transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	353174	n/a
Ensembl	ENSG00000186919	n/a
UniProt	Q401N2	n/a
RefSeq (mRNA)	NM_180990	n/a
RefSeq (protein)	NP_851321.2	n/a
Location (UCSC)	Chr 17: 76.07 – 76.08 Mb	n/a
PubMed search	[2]	n/a
Wikidata

View/Edit Human

Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the rat or mouse genomes.^[3]

ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach.^[3][4] The endogenous ligand for ZAC is thought to be Zn²⁺, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.^[3]

References

1. "Drugs that physically interact with Zinc-activated ligand-gated ion channel view/edit references on wikidata".
2. "Human PubMed Reference:".
3. Davies PA, Wang W, Hales TG, Kirkness EF (2003). "A novel class of ligand-gated ion channel is activated by Zn2+". J. Biol. Chem. 278 (2): 712–7. doi:10.1074/jbc.M208814200. PMID 12381728.
4. Houtani T, Munemoto Y, Kase M, Sakuma S, Tsutsumi T, Sugimoto T (2005). "Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system". Biochem Biophys Res Commun. 335 (2): 227–85. doi:10.1016/j.bbrc.2005.07.079. PMID 16083862.