MSRB2

MSRB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L1U
Identifiers
Aliases	MSRB2, CBS-1, CBS1, MSRB, PILB, CGI-131, methionine sulfoxide reductase B2
External IDs	MGI: 1923717 HomoloGene: 56555 GeneCards: MSRB2
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor • oxidoreductase activity • actin binding • zinc ion binding • metal ion binding • peptide-methionine (R)-S-oxide reductase activity Cellular component • cytosol • mitochondrion Biological process • actin filament polymerization • oxidation-reduction process • response to oxidative stress • protein repair • regulation of transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22921	76467
Ensembl	ENSG00000148450	ENSMUSG00000023094
UniProt	Q9Y3D2	Q78J03
RefSeq (mRNA)	NM_012228	NM_029619
RefSeq (protein)	NP_036360.3	NP_083895.1
Location (UCSC)	Chr 10: 23.1 – 23.12 Mb	Chr 2: 19.37 – 19.39 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Methionine-R-sulfoxide reductase B2, mitochondrial is an enzyme that in humans is encoded by the MSRB2 gene.^[3][4][5] The MRSB2 enzyme catalyzes the reduction of methionine sulfoxide to methionine.

See also

• MSRA (gene)
• Methionine oxidation
• SEPX1

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Escribano J, Ortego J, Coca-Prados M (Jan 1997). "Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins". J Biochem. 118 (5): 921–31. PMID 8749308.
4. Huang W, Escribano J, Sarfarazi M, Coca-Prados M (Aug 1999). "Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases". Gene. 233 (1-2): 233–40. doi:10.1016/S0378-1119(99)00131-6. PMID 10375640.
5. "Entrez Gene: MSRB2 methionine sulfoxide reductase B2".

Further reading

• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Jung S, Hansel A, Kasperczyk H, et al. (2002). "Activity, tissue distribution and site-directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1". FEBS Lett. 527 (1-3): 91–4. doi:10.1016/S0014-5793(02)03171-X. PMID 12220640.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kim HY, Gladyshev VN (2004). "Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases". Mol. Biol. Cell. 15 (3): 1055–64. doi:10.1091/mbc.E03-08-0629. PMC 363075. PMID 14699060.
• Picot CR, Perichon M, Cintrat JC, et al. (2004). "The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts". FEBS Lett. 558 (1-3): 74–8. doi:10.1016/S0014-5793(03)01530-8. PMID 14759519.
• Hansel A, Jung S, Hoshi T, Heinemann SH (2004). "A second human methionine sulfoxide reductase (hMSRB2) reducing methionine-R-sulfoxide displays a tissue expression pattern distinct from hMSRB1". Redox Rep. 8 (6): 384–8. doi:10.1179/135100003225003429. PMID 14980072.
• Schallreuter KU, Rübsam K, Chavan B, et al. (2006). "Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus". Biochem. Biophys. Res. Commun. 342 (1): 145–52. doi:10.1016/j.bbrc.2006.01.124. PMID 16480945.