NEU4

NEU4
Identifiers
Aliases	NEU4
External IDs	MGI: 2661364 HomoloGene: 15433 GeneCards: NEU4
Gene ontology Molecular function • exo-alpha-(2->6)-sialidase activity • exo-alpha-(2->8)-sialidase activity • hydrolase activity, acting on glycosyl bonds • protein binding • exo-alpha-(2->3)-sialidase activity • hydrolase activity • exo-alpha-sialidase activity Cellular component • organelle inner membrane • membrane • lysosomal lumen • mitochondrion • lysosome Biological process • glycosphingolipid metabolic process • carbohydrate metabolic process • lipid metabolic process • lipid catabolic process • glycoprotein catabolic process • oligosaccharide catabolic process • metabolic process • ganglioside catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	129807	241159
Ensembl	n/a	ENSMUSG00000034000
UniProt	Q8WWR8	Q8BZL1
RefSeq (mRNA)	NM_080741 NM_001167599 NM_001167600 NM_001167601 NM_001167602	NM_173772 NM_001310769
RefSeq (protein)	NP_001161071.1 NP_001161072.1 NP_001161073.1 NP_001161074.1 NP_542779.2 NP_001161071.1 NP_001161072.1 NP_001161073.1 NP_001161074.1	NP_001297698.1 NP_776133.1
Location (UCSC)	Chr 2: 241.81 – 241.82 Mb	Chr 1: 94.02 – 94.03 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Sialidase-4 is an enzyme that in humans is encoded by the NEU4 gene.^[3]

Function

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids.^[3]

Interactions

NEU4 has been shown to interact with PLSCR1.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: NEU4 sialidase 4".
4. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Comelli EM, Amado M, Lustig SR, Paulson JC (2004). "Identification and expression of Neu4, a novel murine sialidase.". Gene. 321: 155–61. doi:10.1016/j.gene.2003.08.005. PMID 14637003.
• Monti E, Bassi MT, Bresciani R, Civini S, Croci GL, Papini N, Riboni M, Zanchetti G, Ballabio A, Preti A, Tettamanti G, Venerando B, Borsani G (2004). "Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family.". Genomics. 83 (3): 445–53. doi:10.1016/j.ygeno.2003.08.019. PMID 14962670.
• Seyrantepe V, Landry K, Trudel S, Hassan JA, Morales CR, Pshezhetsky AV (2004). "Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells.". J. Biol. Chem. 279 (35): 37021–9. doi:10.1074/jbc.M404531200. PMID 15213228.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Stamatos NM, Liang F, Nan X, Landry K, Cross AS, Wang LX, Pshezhetsky AV (2005). "Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages.". FEBS J. 272 (10): 2545–56. doi:10.1111/j.1742-4658.2005.04679.x. PMID 15885103.