STAG2

STAG2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PJU, 4PJW, 4PK7
Identifiers
Aliases	STAG2, SA-2, SA2, SCC3B, bA517O1.1, stromal antigen 2
External IDs	MGI: 1098583 HomoloGene: 38206 GeneCards: STAG2
Gene ontology Molecular function • protein binding Cellular component • cytosol • membrane • plasma membrane • chromosome • nucleoplasm • nucleolus • actin cytoskeleton • chromatin • intermediate filament cytoskeleton • chromosome, centromeric region • nucleus Biological process • mitotic nuclear division • chromosome segregation • protein sumoylation • cell division • negative regulation of DNA endoreduplication • meiotic cell cycle • cell cycle • sister chromatid cohesion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10735	20843
Ensembl	ENSG00000101972	ENSMUSG00000025862
UniProt	Q8N3U4	O35638
RefSeq (mRNA)	NM_001042749 NM_001042750 NM_001042751 NM_001282418 NM_006603	NM_001077712 NM_001290713 NM_021465
RefSeq (protein)	NP_001036214.1 NP_001036215.1 NP_001036216.1 NP_001269347.1 NP_006594.3	NP_001071180.1 NP_067440.3
Location (UCSC)	Chr X: 123.96 – 124.42 Mb	Chr X: 42.15 – 42.28 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

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Cohesin subunit SA-2 is a protein that in humans is encoded by the STAG2 gene.^[3][4]

Interactions

STAG2 has been shown to interact with STAG1.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, González de Buitrago G, Aracil M, Márquez G, Barbero JL, Zipori D (August 1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs". Gene. 195 (2): 151–9. doi:10.1016/S0378-1119(97)00121-2. PMID 9305759.
4. "Entrez Gene: STAG2 stromal antigen 2".
5. Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.

Further reading

• Wu C, Friedlander P, Lamoureux C, Zannis-Hadjopoulos M, Price GB (September 1993). "cDNA clones contain autonomous replication activity". Biochimica et Biophysica Acta. 1174 (3): 241–57. doi:10.1016/0167-4781(93)90193-h. PMID 7690594.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
• Gregson HC, Schmiesing JA, Kim JS, Kobayashi T, Zhou S, Yokomori K (December 2001). "A potential role for human cohesin in mitotic spindle aster assembly". The Journal of Biological Chemistry. 276 (50): 47575–82. doi:10.1074/jbc.M103364200. PMID 11590136.
• Prieto I, Pezzi N, Buesa JM, Kremer L, Barthelemy I, Carreiro C, Roncal F, Martinez A, Gomez L, Fernandez R, Martinez-A C, Barbero JL (June 2002). "STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis". EMBO Reports. 3 (6): 543–50. doi:10.1093/embo-reports/kvf108. PMC 1084142. PMID 12034751.
• Lara-Pezzi E, Pezzi N, Prieto I, Barthelemy I, Carreiro C, Martínez A, Maldonado-Rodríguez A, López-Cabrera M, Barbero JL (February 2004). "Evidence of a transcriptional co-activator function of cohesin STAG/SA/Scc3". The Journal of Biological Chemistry. 279 (8): 6553–9. doi:10.1074/jbc.M307663200. PMID 14660624.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Hauf S, Roitinger E, Koch B, Dittrich CM, Mechtler K, Peters JM (March 2005). "Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2". PLoS Biology. 3 (3): e69. doi:10.1371/journal.pbio.0030069. PMC 1054881. PMID 15737063.
• McGuinness BE, Hirota T, Kudo NR, Peters JM, Nasmyth K (March 2005). "Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells". PLoS Biology. 3 (3): e86. doi:10.1371/journal.pbio.0030086. PMC 1054882. PMID 15737064.
• Losada A, Yokochi T, Hirano T (May 2005). "Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts". Journal of Cell Science. 118 (Pt 10): 2133–41. doi:10.1242/jcs.02355. PMID 15855230.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.