Silicone-induced granuloma

Leak of silicone in biological tissues produces an inflammatory reaction, as silicone-induced granuloma (siliconoma).^[1]

Localization

• Lymph node: Granulomatous lymphadenitis^[2][3]
• Skin: Granulomatous dermatitis^[4][5][6]
• Penis^[7]
• Breast: Granulomatous mastitis^[8][9]
• Face: Granulomatous facial reaction ^[10]

Effects

Silicone-induced granuloma can be associated with fever,^[11] calcitriol-mediated hypercalcemia,^[12] reactive amyloidosis.^[13][14][15]

References

1. Ellis, L. Z.; Cohen, J. L.; High, W (2012). "Granulomatous reaction to silicone injection". The Journal of clinical and aesthetic dermatology. 5 (7): 44–7. PMC 3396457. PMID 22798975.
2. Péoc'h, M; Duprez, D; Grice, G; Fabre-Bocquentin, B; Gressin, R; Pasquier, B (2000). "Silicone lymphadenopathy mimicking a lymphoma in a patient with a metatarsophalangeal joint prosthesis". Journal of clinical pathology. 53 (7): 549–51. doi:10.1136/jcp.53.7.549. PMC 1731232. PMID 10961180.
3. García Callejo, F. J.; Calvo González, J; Agustí Martínez, J; Bécares Martínez, C; Monzó Gandía, R; Marco Algarra, J (2013). "Neck lymphadenitis due to silicone granuloma after mammary implants". Acta Otorrinolaringológica Española. 64 (3): 217–22. doi:10.1016/j.otorri.2012.12.003. PMID 23499209.
4. Rieder, E; Desai, S; Mundi, J. P.; Boyd, K. P.; Patel, R. R.; Ramachandran, S; Franks Jr, A. G. (2013). "Granulomatous dermatitis related to silicone implant". Dermatology online journal. 19 (12): 20708. PMID 24364999.
5. El-Charnoubi, W. A.; Foged Henriksen, T; Joergen Elberg, J (2011). "Cutaneous silicone granuloma mimicking breast cancer after ruptured breast implant". Case Reports in Dermatological Medicine. 2011: 129138. doi:10.1155/2011/129138. PMC 3505939. PMID 23198167.
6. Schwartzfarb, E. M.; Hametti, J. M.; Romanelli, P; Ricotti, C (2008). "Foreign body granuloma formation secondary to silicone injection". Dermatology online journal. 14 (7): 20. PMID 18718204.
7. Inn, F. X.; Imran, F. H.; Ali, M. F.; Ih, R; z, Z (2012). "Penile augmentation with resultant foreign material granuloma and sequalae". The Malaysian journal of medical sciences : MJMS. 19 (4): 81–3. PMC 3629684. PMID 23613653.
8. El-Charnoubi, W. A.; Foged Henriksen, T; Joergen Elberg, J (2011). "Cutaneous silicone granuloma mimicking breast cancer after ruptured breast implant". Case Reports in Dermatological Medicine. 2011: 129138. doi:10.1155/2011/129138. PMC 3505939. PMID 23198167.
9. Symmers, W. S. (1968). "Silicone mastitis in "topless" waitresses and some other varieties of foreign-body mastitis". British Medical Journal. 3 (5609): 19–22. doi:10.1136/bmj.3.5609.8-a. PMC 1989508. PMID 5690841.
10. Poveda, R; Bagán, J. V.; Murillo, J; Jiménez, Y (2006). "Granulomatous facial reaction to injected cosmetic fillers--a presentation of five cases". Medicina oral, patologia oral y cirugia bucal. 11 (1): E1–5. PMID 16388285.
11. Blum, A; Abboud, W; Shajrawi, I; Tatour, I (2007). "Prolonged fever due to silicone granulomatosis". The Israel Medical Association journal : IMAJ. 9 (2): 121–2. PMID 17348488.
12. Agrawal, N; Altiner, S; Mezitis, N. H.; Helbig, S (2013). "Silicone-induced granuloma after injection for cosmetic purposes: A rare entity of calcitriol-mediated hypercalcemia". Case Reports in Medicine. 2013: 807292. doi:10.1155/2013/807292. PMC 3864076. PMID 24363673.
13. d'Ythurbide, G; Kerrou, K; Brocheriou, I; Hertig, A (2012). "Reactive amyloidosis complicated by end-stage renal disease 28 years after liquid silicone injection in the buttocks". Case Reports. 2012: bcr2012006803. doi:10.1136/bcr-2012-006803. PMID 23035166.
14. Emekli, U; Tümerdem, B; Demiryont, M (2002). "Rupture of a silicone gel mammary prosthesis and amyloidosis: A case report". Aesthetic Plastic Surgery. 26 (5): 383–7. doi:10.1007/s00266-002-2022-x. PMID 12432480.
15. Goldman, A. B.; Bansal, M (1996). "Amyloidosis and silicone synovitis: Updated classification, updated pathophysiology, and synovial articular abnormalities". Radiologic clinics of North America. 34 (2): 375–94, xi. PMID 8633122.