Granulomatous mastitis

Granulomatous mastitis
Classification and external resources

Granulomatous mastitis can be divided into idiopathic granulomatous mastitis (also known as granular lobular mastitis[1]) and granulomatous mastitis occurring as a rare secondary complication of a great variety of other conditions such as tuberculosis and other infections, sarcoidosis and granulomatosis with polyangiitis. Special forms of granulomatous mastitis occur as complication of diabetes. Some cases are due to silicone injection (Silicone-induced granulomatous inflammation) or other foreign body reactions.[2][3]

Primary presentation of any of these conditions as mastitis is very rare and in many cases probably predisposed by other breast or systemic conditions.

Although granulomatous mastitis is easily confused with cancer it is a completely benign (non-cancerous) condition.

Treatment is radically different for idiopathic granulomatous mastitis and other granulomatous lesions of the breast, the precise diagnosis is therefore very important.

Idiopathic granulomatous mastitis

Idiopathic granulomatous mastitis is defined as granulomatous mastits without any other attributable cause such as those above mentioned. It occurs on average two years and almost exclusively up to six years after pregnancy, usual age range is 17 to 42 years. Some cases have been reported that were related to drug induced hyperprolactinemia.[4][5]

Exceptionally rarely it has been diagnosed during pregnancy and in men.[6][7]

Symptoms and diagnosis

Patients mostly present with a hard lump in one breast without any sign of a systemic disease. Other possible symptoms include nipple retraction, pain, inflammation of the overlying skin, nipple discharge, fistula, enlarged lymph nodes, in rare case peau d'orange-like changes.

Presentation is mostly unilateral although a significant share of cases is bilateral, also in many cases contralateral or bilateral recurrences were documented.

Several cases occurring together with fever, polyarthralgia and erythema nodosum were documented.

Characteristic for idiopathic granulomatous mastitis are multinucleated giant cells and epithelioid histiocytes forming non-caseating granulomas around lobules. Often minor ductal and periductal inflammation is present. The lesion is in some cases very difficult to distinguish from breast cancer and other causes such as infections (tuberculosis, syphilis, corynebacterial infection, mycotic infection), autoimmune diseases (sarcoidosis, granulomatosis with polyangiitis), foreign body reaction and granulomatous reaction in a carcinoma must be excluded.[4][8]

The condition is diagnosed very rarely. As the diagnosis is a lengthy differential diagnosis of exclusion there is considerable uncertainty about incidence. It has been suspected that some cases diagnosed as IGM in developing countries may have other explanations. On the other hand, IGM is usually diagnosed only after complications and referral to a secondary breast care center so light cases may resolve spontaneously or after symptomatic treatment and thus never be diagnosed as IGM. As a completely pathogen free breast will be exceedingly rare even in completely healthy population there is also uncertainty when to consider pathogens as causative or as mere coincidental finding.

Causes

The cause is currently unknown. The histology is suggestive of an autoimmune reaction. The high rate of relapses as well as relatively high proportion of bilateral cases is highly suggestive of a systemic predisposition.

Presently most evidence points towards an important role of elevated prolactin levels or overt hyperprolactinemia with additional triggers such as local trauma or irritation. Alpha 1-antitrypsin deficiency was documented in one case, interferon-alpha therapy in another case. Similar cases of granulomatous mastitis were reported in IgG4-related disease though the exact relationship to IGM remains to be elucidated. Other contributing factors of IGM were investigated such as oral contraceptives usage. Many cases were reported after use of prolactin elevating medications such as antipsychotics.[4][5][9][10][11]

Elevated prolactin levels have the direct effects of increasing secretory activity of breast lobules, maintaining tight junctions of the ductal epithelium, preventing involution of the breast gland after weaning and are known to stimulate the immune system, contributing to both physiological and pathological granulomatous lesions and non-caseating granulomas.[4] PRL is also secreted locally in the breast and local secretion by lymphocytes may be enhanced during inflammatory reactions.[12] Autoimmune reaction to extravasated fat and protein rich luminal fluid (denaturized milk) resulting from the secretory activity is assumed to be one of the triggers of IGM.[4][13] Several other hormones can contribute to PRL signaling in the breast gland, high levels of insulin caused for example by peripheral insulin resistance (resulting from pregnancy, gestational diabetes or developing diabetes mellitus type 2) will enhance the galactogenic and antiapoptotic effects of PRL and growth hormone by acting synergistically with IGF-1.

Treatment

Treatment protocol is not well established. Some sources report that approximately half of the patients will fully recover after lengthy (mean time 14.5 months, range 2–24 months) expectant management.[14]

Treatment with steroids is lengthy and usually requires about 6 months. While some source report very good success with steroids[15] most report a considerable risk of recurrence after a treatment with steroids alone. Steroids are known to cause elevation of prolactin levels and increase risk of several conditions such as diabetes, and other endocrinopathies which in turn increase the risk of IGM. Treatment with topical steroids to limit side effects was also reported in one case.[16] For surgical treatment recurrence rates of 5-50% have been reported.[4]

A 1997 literature review article recommended complete resection or corticosteroid therapy, stating also that long-term follow-up was indicated due to a high rate of recurrence.[17]

Treatment with a combination of glucocorticoids and prolactin lowering medications such as bromocriptine or cabergoline was used with good success in Germany.[18] Prolactin lowering medication has also been reported to reduce the risk of recurrence.[19] In cases of drug-induced hyperprolactinemia (such as antipsychotics) prolactin-sparing medication can be tried.[4]

Methotrexate alone or in combination with steroids has been used with good success. Its principal mechanism of action is immunomodulating activity, with a side effect profile that is more favorable for treating IGM.[20]

Colchicine, azathioprine and NSAIDs have also been used.[21][22]

References

  1. ↑ Garcia-Rodiguez JA, Pattullo A (2013). "Idiopathic granulomatous mastitis: a mimicking disease in a pregnant woman: a case report". BMC Research Notes. 6 (95). doi:10.1186/1756-0500-6-95.
  2. ↑ El-Charnoubi, W. A.; Foged Henriksen, T; Joergen Elberg, J (2011). "Cutaneous silicone granuloma mimicking breast cancer after ruptured breast implant". Case Reports in Dermatological Medicine. 2011: 129138. doi:10.1155/2011/129138. PMC 3505939Freely accessible. PMID 23198167.
  3. ↑ Symmers, W. S. (1968). "Silicone mastitis in "topless" waitresses and some other varieties of foreign-body mastitis". British Medical Journal. 3 (5609): 19–22. doi:10.1136/bmj.3.5609.8-a. PMC 1989508Freely accessible. PMID 5690841.
  4. 1 2 3 4 5 6 7 Lin, C. H.; Hsu, C. W.; Tsao, T. Y.; Chou, J. (2012). "Idiopathic granulomatous mastitis associated with risperidone-induced hyperprolactinemia". Diagnostic Pathology. 7 (1): 2. doi:10.1186/1746-1596-7-2. PMC 3261802Freely accessible. PMID 22221904.
  5. 1 2 Bellavia, M.; Damiano, G.; Palumbo, V. D.; Spinelli, G.; Tomasello, G.; Marrazzo, A.; Ficarella, S.; Bruno, A.; Sammartano, A.; Fiorentini, T.; Scio, A.; Maione, C.; Lo Monte, A. I. (2012). "Granulomatous Mastitis during Chronic Antidepressant Therapy: Is It Possible a Conservative Therapeutic Approach?". Journal of Breast Cancer. 15 (3): 371–372. doi:10.4048/jbc.2012.15.3.371. PMC 3468794Freely accessible. PMID 23091553.
  6. ↑ Reddy, K. M.; Meyer, C. E. R.; Nakdjevani, A.; Shrotria, S. (2005). "Idiopathic Granulomatous Mastitis in the Male Breast". The Breast Journal. 11 (1): 73. doi:10.1111/j.1075-122X.2005.21404.x. PMID 15647084.
  7. ↑ Goldberg, J.; Baute, L.; Storey, L.; Park, P. (2000). "Granulomatous mastitis in pregnancy". Obstetrics and gynecology. 96 (5 Pt 2): 813–815. doi:10.1016/S0029-7844(00)01051-6. PMID 11094217.
  8. ↑ Seo, H. R. N.; Na, K. Y.; Yim, H. E.; Kim, T. H.; Kang, D. K.; Oh, K. K.; Kang, S. Y.; An, Y. S.; Chun, M.; Kim, W.; Park, R. W.; Jung, Y. S.; Kim, K. S. (2012). "Differential Diagnosis in Idiopathic Granulomatous Mastitis and Tuberculous Mastitis". Journal of Breast Cancer. 15 (1): 111–118. doi:10.4048/jbc.2012.15.1.111. PMC 3318162Freely accessible. PMID 22493637.
  9. ↑ Schelfout, K.; Tjalma, W. A.; Cooremans, I. D.; Coeman, D. C.; Colpaert, C. G.; Buytaert, P. M. (2001). "Observations of an idiopathic granulomatous mastitis". European journal of obstetrics, gynecology, and reproductive biology. 97 (2): 260–262. doi:10.1016/s0301-2115(00)00546-7. PMID 11451563.
  10. ↑ Shaaban, H.; Slim, J.; Choo, H. (2012). "Idiopathic granulomatous mastitis as a complication of interferon-alpha therapy". North American Journal of Medical Sciences. 4 (9): 424–426. doi:10.4103/1947-2714.101005. PMC 3456487Freely accessible. PMID 23050257.
  11. ↑ Ogura, K.; Matsumoto, T.; Aoki, Y.; Kitabatake, T.; Fujisawa, M.; Kojima, K. (2010). "IgG4-related tumour-forming mastitis with histological appearances of granulomatous lobular mastitis: Comparison with other types of tumour-forming mastitis". Histopathology. 57 (1): 39–45. doi:10.1111/j.1365-2559.2010.03581.x. PMID 20653779.
  12. ↑ Shelly, S.; Boaz, M.; Orbach, H. (2012). "Prolactin and autoimmunity". Autoimmunity Reviews. 11 (6–7): A465–A470. doi:10.1016/j.autrev.2011.11.009. PMID 22155203.
  13. ↑ Bässler, R. (1997). "Mastitis. Classification, histopathology and clinical aspects". Der Pathologe. 18 (1): 27–36. PMID 9157401.
  14. ↑ Lai, E. C. H.; Chan, W. C.; Ma, T. K. F.; Tang, A. P. Y.; Poon, C. S. P.; Leong, H. T. (2005). "The Role of Conservative Treatment in Idiopathic Granulomatous Mastitis". The Breast Journal. 11 (6): 454–456. doi:10.1111/j.1075-122X.2005.00127.x. PMID 16297091.
  15. ↑ Aldaqal, S. M. (2004). "Idiopathic granulomatous mastitis. Clinical presentation, radiological features and treatment". Saudi medical journal. 25 (12): 1884–1887. PMID 15711659.
  16. ↑ Altintoprak, F. (2011). "Topical Steroids to Treat Granulomatous Mastitis: A Case Report". The Korean Journal of Internal Medicine. 26 (3): 356–359. doi:10.3904/kjim.2011.26.3.356. PMC 3192210Freely accessible. PMID 22016598.
  17. ↑ Imoto S, Kitaya T, Kodama T, Hasebe T, Mukai K (August 1997). "Idiopathic granulomatous mastitis: case report and review of the literature". Japanese Journal of Clinical Oncology (review). 27 (4): 274–7. PMID 9379518.
  18. ↑ Krause, A.; Gerber, B.; Rhode, E. (1994). "Puerperal and non-puerperal mastitis". Zentralblatt für Gynäkologie. 116 (8): 488–491. PMID 7941820.
  19. ↑ Erhan, Y.; Veral, A.; Kara, E.; Ozdemir, N.; Kapkac, M.; Ozdedeli, E.; Yilmaz, R.; Koyuncu, A.; Erhan, Y.; Ozbal, O. (2000). "A clinicopthologic study of a rare clinical entity mimicking breast carcinoma: Idiopathic granulomatous mastitis". The Breast. 9 (1): 52–56. doi:10.1054/brst.1999.0072. PMID 14731585.
  20. ↑ Akbulut, S.; Arikanoglu, Z.; Senol, A.; Sogutcu, N.; Basbug, M.; Yeniaras, E.; Yagmur, Y. (2011). "Is methotrexate an acceptable treatment in the management of idiopathic granulomatous mastitis?". Archives of Gynecology and Obstetrics. 284 (5): 1189–1195. doi:10.1007/s00404-010-1825-2. PMID 21207047.
  21. ↑ Ayeva-Derman, M.; Perrotin, F.; Lefrancq, T.; Roy, F.; Lansac, J.; Body, G. (1999). "Idiopathic granulomatous mastitis. Review of the literature illustrated by 4 cases". Journal de gynecologie, obstetrique et biologie de la reproduction. 28 (8): 800–807. PMID 10635482.
  22. ↑ Vingerhoedt, N. M.; Janssen, S.; Mravunac, M.; Wauters, C. A.; Strobbe, L. J. (2008). "Granulomatous lobular mastitis: A benign abnormality that mimics malignancy". Nederlands tijdschrift voor geneeskunde. 152 (18): 1052–1056. PMID 18547028.
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