ITGA6

ITGA6
Identifiers
Aliases	ITGA6, CD49f, ITGA6B, VLA-6, integrin subunit alpha 6
External IDs	MGI: 96605 HomoloGene: 20091 GeneCards: ITGA6
Genetically Related Diseases
prostate cancer[1]
Gene ontology Molecular function • metal ion binding • integrin binding • protein binding • laminin binding • neuregulin binding • cadherin binding involved in cell-cell adhesion • protein complex binding • insulin-like growth factor I binding Cellular component • integral component of membrane • membrane • focal adhesion • basal part of cell • plasma membrane • hemidesmosome • basement membrane • cell surface • integrin complex • basal plasma membrane • basolateral plasma membrane • external side of plasma membrane • integrin alpha6-beta4 complex • filopodium • cell-cell adherens junction Biological process • cellular response to extracellular stimulus • hemidesmosome assembly • renal system development • nail development • positive regulation of cell-cell adhesion • filopodium assembly • negative regulation of extrinsic apoptotic signaling pathway • extracellular matrix organization • odontogenesis of dentin-containing tooth • cell-substrate adhesion • positive regulation of GTPase activity • cell adhesion • cell adhesion mediated by integrin • brown fat cell differentiation • positive regulation of apoptotic process • cell-substrate junction assembly • integrin-mediated signaling pathway • positive regulation of phosphorylation • cell-matrix adhesion • digestive tract development • ectodermal cell differentiation • leukocyte migration • skin development • positive regulation of transcription from RNA polymerase II promoter • amelogenesis • cellular response to organic cyclic compound • positive regulation of cell-substrate adhesion • single organismal cell-cell adhesion • positive regulation of cell migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3655	16403
Ensembl	ENSG00000091409	ENSMUSG00000027111
UniProt	P23229	Q61739
RefSeq (mRNA)	NM_000210 NM_001079818 NM_001316306	NM_001277970 NM_008397
RefSeq (protein)	NP_000201.2 NP_001073286.1 NP_001303235.1	NP_001264899.1
Location (UCSC)	Chr 2: 172.43 – 172.51 Mb	Chr 2: 71.75 – 71.86 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

Function

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.^[4]

Interactions

ITGA6 has been shown to interact with TSPAN4^[5] and GIPC1.^[6]

See also

• Cluster of differentiation
• Integrins

References

1. "Diseases that are genetically associated with ITGA6 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. "Entrez Gene: ITGA6 integrin, alpha 6".
5. Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". The Journal of Biological Chemistry. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
6. Tani TT, Mercurio AM (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". The Journal of Biological Chemistry. 276 (39): 36535–42. doi:10.1074/jbc.M105785200. PMID 11479315.

Further reading

• Lipscomb EA, Mercurio AM (September 2005). "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression". Cancer Metastasis Reviews. 24 (3): 413–23. doi:10.1007/s10555-005-5133-4. PMID 16258729.

External links

• CD49f Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
• ITGA6 Info with links in the Cell Migration Gateway