CLCA4

CLCA4
Identifiers
Aliases	CLCA4, CaCC, CaCC2, chloride channel accessory 4
External IDs	MGI: 2139744 HomoloGene: 40808 GeneCards: CLCA4
Gene ontology Molecular function • intracellular calcium activated chloride channel activity • peptidase activity • hydrolase activity • metallopeptidase activity • metal ion binding • chloride channel activity • metalloendopeptidase activity Cellular component • integral component of membrane • extracellular region • plasma membrane • integral component of plasma membrane • extracellular exosome • apical plasma membrane • membrane Biological process • ion transmembrane transport • chloride transport • proteolysis • transport • chloride transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22802	99663
Ensembl	ENSG00000016602	ENSMUSG00000068547
UniProt	Q14CN2	Q6Q473
RefSeq (mRNA)	NM_012128	NM_207208
RefSeq (protein)	NP_036260.2	n/a
Location (UCSC)	Chr 1: 86.55 – 86.58 Mb	Chr 3: 144.95 – 144.98 Mb
PubMed search	[1]	[2]
Wikidata

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Chloride channel accessory 4, also known as CLCA4, is a protein which in humans CLCA4 gene. The protein encoded by this gene is a chloride channel.^[3] Protein structure prediction methods suggest the N-terminal region of CLCA4 protein is a zinc metalloprotease, and the protein is not an ion channel per se.^[4]

See also

• Chloride channel

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Agnel M, Vermat T, Culouscou JM (July 1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. doi:10.1016/S0014-5793(99)00891-1. PMID 10437792.
4. Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels.". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849.

Further reading

• Liu QH, Williams DA, McManus C, et al. (2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation.". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. doi:10.1073/pnas.090521697. PMC 18318. PMID 10758170.
• Ritzka M, Stanke F, Jansen S, et al. (2004). "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.". Hum. Genet. 115 (6): 483–91. doi:10.1007/s00439-004-1190-y. PMID 15490240.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Pauli BU, Abdel-Ghany M, Cheng HC, et al. (2000). "Molecular characteristics and functional diversity of CLCA family members.". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5. doi:10.1046/j.1440-1681.2000.03358.x. PMID 11071307.

External links

• CLCA3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)