TRPC1

TRPC1
Identifiers
Aliases	TRPC1, HTRP-1, TRP1, transient receptor potential cation channel subfamily C member 1
External IDs	OMIM: 602343 MGI: 109528 HomoloGene: 2478 GeneCards: TRPC1
Targeted by Drug
2-aminoethoxydiphenylborate[1]
Gene ontology Molecular function • store-operated calcium channel activity • ion channel binding • calcium channel activity • inositol 1,4,5 trisphosphate binding • ion channel activity • protein binding • cation channel activity Cellular component • integral component of membrane • membrane • receptor complex • plasma membrane • integral component of plasma membrane Biological process • melanin biosynthetic process • regulation of cardiac conduction • regulation of cytosolic calcium ion concentration • positive regulation of release of sequestered calcium ion into cytosol • ion transport • response to calcium ion • calcium ion transmembrane transport • transport • manganese ion transport • calcium ion transport • transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7220	22063
Ensembl	ENSG00000144935	ENSMUSG00000032839
UniProt	P48995	Q61056
RefSeq (mRNA)	NM_001251845 NM_003304	NM_011643 NM_001311123
RefSeq (protein)	NP_001238774.1 NP_003295.1	NP_001298052.1 NP_035773.1
Location (UCSC)	Chr 3: 142.72 – 142.81 Mb	Chr 9: 95.71 – 95.75 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Transient receptor potential channel 1 (TRPC1) is a protein that in humans is encoded by the TRPC1 gene.^[4][5]

Function

TRPC1 is an ion channel located on the plasma membrane of numerous human and animal cell types. ^[6] It is a nonspecific cation channel, which means that both sodium and calcium ions can pass through it. TRPC1 is thought to mediate calcium entry in response to depletion of endoplasmic calcium stores or activation of receptors coupled to the phospholipase C system. In HEK293 cells the unitary current-voltage relationship of endogenous TRPC1 channels is almost linear, with a slope conductance of about 17 pS. The extrapolated reversal potential of TRPC1 channels is +30 mV.^[7] The TRPC1 protein is widely expressed throughout the mammalian brain and has a similar corticolimbic expression pattern as TRPC4 and TRPC5. ^[8][9] The highest density of TRPC1 protein is found in the lateral septum, an area with dense TRPC4 expression, and hippocampus and prefrontal cortex, areas with dense TRPC5 expression.^[9]

History

TRPC1 was the first mammalian Transient Receptor Potential channel to be identified. In 1995 it was cloned when the research groups headed by Craig Montell and Lutz Birnbaumer were searching for proteins similar to the TRP channel in Drosophila. Together with TRPC3 they became the founding members of the TRPC ion channel family.^[4][5]

Interactions

TRPC1 has been shown to interact with:

• HOMER3,^[10]
• Polycystic kidney disease 2,^[11]
• RHOA^[12]
• TRPC3,^[13][14]
• TRPC4,^[13][15] and
• TRPC5.^[13][15]

See also

• TRPC

References

1. "Drugs that physically interact with Short transient receptor potential channel 1 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Wes PD, Chevesich J, Jeromin A, Rosenberg C, Stetten G, Montell C (Oct 1995). "TRPC1, a human homolog of a Drosophila store-operated channel". Proceedings of the National Academy of Sciences of the United States of America. 92 (21): 9652–6. doi:10.1073/pnas.92.21.9652. PMC 40860. PMID 7568191.
5. Zhu X, Chu PB, Peyton M, Birnbaumer L (Oct 1995). "Molecular cloning of a widely expressed human homologue for the Drosophila trp gene". FEBS Letters. 373 (3): 193–8. doi:10.1016/0014-5793(95)01038-G. PMID 7589464.
6. Xu SZ, Beech DJ (Jan 2001). "TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells". Circulation Research. 88 (1): 84–7. doi:10.1161/01.res.88.1.84. PMID 11139478.
7. Skopin A, Shalygin A, Vigont V, Zimina O, Glushankova L, Mozhayeva GN, Kaznacheyeva E (Feb 2013). "TRPC1 protein forms only one type of native store-operated channels in HEK293 cells". Biochimie. 95 (2): 347–53. doi:10.1016/j.biochi.2012.10.004. PMID 23079337.
8. Fowler MA, Sidiropoulou K, Ozkan ED, Phillips CW, Cooper DC (2007). "Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain". PLOS ONE. 2 (6): e573. Bibcode:2007PLoSO...2..573F. doi:10.1371/journal.pone.0000573. PMC 1892805. PMID 17593972.
9. Cooper, Donald; Fowler, Melissa; Varnell, Andrew; Dietrich, A.; Birnbaumer, L.; Cooper, Donald (2012). "Deletion of the trpc1 gene and the effects on locomotor and conditioned place-preference responses to cocaine". Nature Precedings. doi:10.1038/npre.2012.7153.
10. Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell. 114 (6): 777–89. doi:10.1016/s0092-8674(03)00716-5. PMID 14505576.
11. Tsiokas L, Arnould T, Zhu C, Kim E, Walz G, Sukhatme VP (Mar 1999). "Specific association of the gene product of PKD2 with the TRPC1 channel". Proceedings of the National Academy of Sciences of the United States of America. 96 (7): 3934–9. doi:10.1073/pnas.96.7.3934. JSTOR 47742. PMC 22398. PMID 10097141.
12. Mehta D, Ahmmed GU, Paria BC, Holinstat M, Voyno-Yasenetskaya T, Tiruppathi C, Minshall RD, Malik AB (Aug 2003). "RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability". The Journal of Biological Chemistry. 278 (35): 33492–500. doi:10.1074/jbc.M302401200. PMID 12766172.
13. Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE (Oct 2003). "Formation of novel TRPC channels by complex subunit interactions in embryonic brain". The Journal of Biological Chemistry. 278 (40): 39014–9. doi:10.1074/jbc.M306705200. PMID 12857742.
14. Xu XZ, Li HS, Guggino WB, Montell C (Jun 1997). "Coassembly of TRP and TRPL produces a distinct store-operated conductance". Cell. 89 (7): 1155–64. doi:10.1016/s0092-8674(00)80302-5. PMID 9215637.
15. Hofmann T, Schaefer M, Schultz G, Gudermann T (May 2002). "Subunit composition of mammalian transient receptor potential channels in living cells". Proceedings of the National Academy of Sciences of the United States of America. 99 (11): 7461–6. doi:10.1073/pnas.102596199. PMC 124253. PMID 12032305.

Further reading

• Rychkov G, Barritt GJ (2007). "TRPC1 Ca(2+)-permeable channels in animal cells". Handbook of Experimental Pharmacology. Handbook of Experimental Pharmacology. 179 (179): 23–52. doi:10.1007/978-3-540-34891-7_2. ISBN 978-3-540-34889-4. PMID 17217049.
• Ambudkar IS (Feb 2007). "TRPC1: a core component of store-operated calcium channels". Biochemical Society Transactions. 35 (Pt 1): 96–100. doi:10.1042/BST0350096. PMID 17233611.

External links

• TRPC1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• "TRIP Database". a manually curated database of protein-protein interactions for mammalian TRP channels.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.