DNAJC10

DNAJC10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3APO, 3APQ, 3APS
Identifiers
Aliases	DNAJC10, ERdj5, JPDI, MTHr, PDIA19, DnaJ heat shock protein family (Hsp40) member C10
External IDs	MGI: 1914111 HomoloGene: 10358 GeneCards: DNAJC10
Gene ontology Molecular function • ATPase binding • misfolded protein binding • Hsp70 protein binding • protein binding • oxidoreductase activity • chaperone binding • ATPase activator activity • disulfide oxidoreductase activity • oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor • protein disulfide oxidoreductase activity Cellular component • membrane • endoplasmic reticulum chaperone complex • endoplasmic reticulum lumen • endoplasmic reticulum Biological process • negative regulation of protein phosphorylation • cell redox homeostasis • response to endoplasmic reticulum stress • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • ER-associated ubiquitin-dependent protein catabolic process • oxidation-reduction process • positive regulation of ATPase activity • protein folding in endoplasmic reticulum Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54431	66861
Ensembl	ENSG00000077232	ENSMUSG00000027006
UniProt	Q8IXB1	Q9DC23
RefSeq (mRNA)	NM_001271581 NM_018981	NM_024181
RefSeq (protein)	NP_001258510.1 NP_061854.1	NP_077143.2
Location (UCSC)	Chr 2: 182.72 – 182.79 Mb	Chr 2: 80.32 – 80.35 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

DnaJ homolog subfamily C member 10 is a protein that in humans is encoded by the DNAJC10 gene.^[3][4][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Cunnea PM, Miranda-Vizuete A, Bertoli G, Simmen T, Damdimopoulos AE, Hermann S, Leinonen S, Huikko MP, Gustafsson JA, Sitia R, Spyrou G (Jan 2003). "ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress". J Biol Chem. 278 (2): 1059–66. doi:10.1074/jbc.M206995200. PMID 12411443.
4. Hosoda A, Kimata Y, Tsuru A, Kohno K (Jan 2003). "JPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifs". J Biol Chem. 278 (4): 2669–76. doi:10.1074/jbc.M208346200. PMID 12446677.
5. "Entrez Gene: DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Gu SH, Chen JZ, Ying K, et al. (2004). "Cloning and identification of a novel cDNA which encodes a putative protein with a DnaJ domain and a thioredoxin active motif, human macrothioredoxin.". Biochem. Genet. 41 (7-8): 245–53. doi:10.1023/A:1025510502147. PMID 14587667.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.