Propylpyrazoletriol
Identifiers | |
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CAS Number | 263717-53-9 |
PubChem (CID) | 6095481 |
ChemSpider | 16142497 |
Chemical and physical data | |
Formula | C24H22N2O3 |
Molar mass | 386.44308 g/mol |
3D model (Jmol) | Interactive image |
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Propylpyrazoletriol (PPT) is a synthetic, non-steroidal agonist of ERα with 400-fold selectivity over ERβ[1] that is used widely in scientific research to study the function of ERα.[2][3][4] Though originally thought to be highly selective for ERα, PPT has subsequently been found to also act as an agonist of the GPER (GPR30).[5]
See also
- Methylpiperidinopyrazole (MPP)
- Diarylpropionitrile (DPN)
- Prinaberel (ERB-041)
- Liquiritigenin
- Menerba
- PHTPP
- (R,R)-Tetrahydrochrysene ((R,R)-THC)
References
- ↑ Eckhard Ottow; Hilmar Weinmann (8 September 2008). Nuclear Receptors as Drug Targets. John Wiley & Sons. pp. 50–. ISBN 978-3-527-62330-3.
- ↑ Tony M. Plant; Anthony J. Zeleznik (15 November 2014). Knobil and Neill's Physiology of Reproduction: Two-Volume Set. Academic Press. pp. 2311–. ISBN 978-0-12-397769-4.
- ↑ Cytoplasmic and Nuclear Receptors—Advances in Research and Application: 2012 Edition. ScholarlyEditions. 26 December 2012. pp. 220–. ISBN 978-1-4649-9741-9.
- ↑ Synthesis of Non-steroidal Estrogen Receptor Proteolysis Targeting Chimeric Molecules (PROTACS). ProQuest. 2008. pp. 11–. ISBN 978-0-549-90990-3.
- ↑ Prossnitz, Eric R.; Barton, Matthias (2014). "Estrogen biology: New insights into GPER function and clinical opportunities". Molecular and Cellular Endocrinology. 389 (1-2): 71–83. doi:10.1016/j.mce.2014.02.002. ISSN 0303-7207.
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