AB-CHFUPYCA

AB-CHFUPYCA

Legal status
Legal status	CA: Schedule II
Identifiers
IUPAC name N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide
CAS Number	none
Chemical and physical data
Formula	C22H29FN4O2
Molar mass	400.50 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(NC(C(N)=O)C(C)C)C1=CC(C2=CC=C(F)C=C2)=NN1CC3CCCCC3
InChI InChI=1S/C22H29FN4O2/c1-14(2)20(21(24)28)25-22(29)19-12-18(16-8-10-17(23)11-9-16)26-27(19)13-15-6-4-3-5-7-15/h8-12,14-15,20H,3-7,13H2,1-2H3,(H2,24,28)(H,25,29) Key:NDYOOVJIZQTGHY-UHFFFAOYSA-N

AB-CHFUPYCA (also AB-CHMFUPPYCA)^[1] is a compound that was first identified as a component of synthetic cannabis products in Japan in 2015.^[2][3] The name "AB-CHFUPYCA" is an acronym of its systematic name N-(1-Amino-3-methyl-1-oxoButan-2-yl)-1-(CycloHexylmethyl)-3-(4-FlUorophenyl)-1H-PYrazole-5-CarboxAmide.

Although AB-CHFUPYCA contains structural elements common to the synthetic cannabinoid designer drugs AB-PINACA and AB-FUBINACA, it can also be considered an analog of the traditional pyrazole cannabinoid receptor 1 antagonist rimonabant. Its pharmacological properties have been the subject of only very limited study; it is presumed to be a potent agonist of the CB₁ receptor.

See also

• 5F-AB-FUPPYCA
• 5F-AB-PINACA
• 5F-ADB
• 5F-AMB
• 5F-APINACA
• AB-CHMFUPPYCA
• AB-FUBINACA
• AB-PINACA
• ADB-CHMINACA
• ADB-FUBINACA
• ADB-PINACA
• ADBICA
• APICA
• APINACA
• MDMB-CHMICA
• Rimonabant

References

1. Gavin McLaughlin; Noreen Morris; Pierce V. Kavanagh; John D. Power; Brendan Twamley; John O'Brien; Brian Talbot; Geraldine Dowling; Simon D. Brandt (September 2015). "The synthesis and characterization of the 'research chemical' N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide (3,5-AB-CHMFUPPYCA) and differentiation from its 5,3-regioisomer". Drug Testing and Analysis. doi:10.1002/dta.1864.
2. Uchiyama, N.; Asakawa, K.; Kikura-Hanajiri, R.; Tsutsumi, T.; Hakamatsuka, T. (August 2015). "A new pyrazole-carboxamide type synthetic cannabinoid AB-CHFUPYCA [N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide] identified in illegal products". Forensic Toxicology. 33 (2): 367–373. doi:10.1007/s11419-015-0283-8.
3. Florian Franz; Verena Angerer; Simon D. Brandt; Gavin McLaughlin; Pierce V. Kavanagh; Bjoern Moosmann; Volker Auwärter (2016). "In vitro metabolism of the synthetic cannabinoid 3,5-AB-CHMFUPPYCA and its 5,3-regioisomer and investigation of their thermal stability". Drug Testing and Analysis. doi:10.1002/dta.1950.