QUCHIC

QUCHIC

Legal status
Legal status	CA: Schedule II DE: Anlage II (Prohibited) Temporary Class Drug (NZ)
Identifiers
IUPAC name 1-(cyclohexylmethyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester
CAS Number	1400742-42-8
PubChem (CID)	71711120
ChemSpider	29339967
Chemical and physical data
Formula	C25H24N2O2
Molar mass	384.47 g/mol
3D model (Jmol)	Interactive image
SMILES C1CCC(CC1)CN2C=C(C3=CC=CC=C32)C(=O)OC4=CC=CC5=C4N=CC=C5
InChI InChI=1S/C25H24N2O2/c28-25(29-23-14-6-10-19-11-7-15-26-24(19)23)21-17-27(16-18-8-2-1-3-9-18)22-13-5-4-12-20(21)22/h4-7,10-15,17-18H,1-3,8-9,16H2 Key:RHYGTJXOHOGQGI-UHFFFAOYSA-N

QUCHIC (BB-22 or 1-(cyclohexylmethyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester) is a designer drug offered by online vendors as a cannabimimetic agent, and was first detected being sold in synthetic cannabis products in Japan in early 2013,^[1] and subsequently also in New Zealand.^[2] The structure of QUCHIC appears to utilise an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear. QUCHIC, along with QUPIC, represents a structurally unique synthetic cannabinoid chemotype since it contains an ester linker at the indole 3-position rather than the precedented ketone of JWH-018 and its analogues, or the amide of SDB-001 and its analogues.

Pharmacology

BB-22 acts as a full agonist with a binding affinity of 0.217nM at CB₁ and 0.338nM at CB₂ cannabinoid receptors.^[3]

See also

• 5F-PB-22
• JWH-018
• PB-22
• QUPIC
• SDB-001
• SDB-005

References

1. Uchiyama, N.; Matsuda, S.; Kawamura, M.; Kikura-Hanajiri, R.; Goda, Y. (2013). "Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products". Forensic Toxicology. doi:10.1007/s11419-013-0182-9.
2. Dunne bans further two substances found in K2. Press Release: New Zealand Government. Tuesday, 30 April 2013
3. Hess, Cornelius; Schoeder, ClaraT.; Pillaiyar, Thanigaimalai; Madea, Burkhard; Müller, ChristaE. (1 July 2016). "Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice". Forensic Toxicology. 34 (2): 329–343. doi:10.1007/s11419-016-0320-2. ISSN 1860-8965. PMC 4929166. PMID 27429655.