HU-336

HU-336

Identifiers
IUPAC name (6aR,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-1H-benzo[c]chromene-1,4(6H)-dione
PubChem (CID)	11370880
ChemSpider	9545797
Chemical and physical data
Formula	C21H28O3
Molar mass	328.445 g/mol
3D model (Jmol)	Interactive image
SMILES O=C\2C=1OC([C@H]3[C@H](C=1C(=O)/C=C/2CCCCC)C/C(=C\C3)C)(C)C
InChI InChI=1S/C21H28O3/c1-5-6-7-8-14-12-17(22)18-15-11-13(2)9-10-16(15)21(3,4)24-20(18)19(14)23/h9,12,15-16H,5-8,10-11H2,1-4H3/t15-,16-/m1/s1 Key:GOZGLSHDDOJPJS-HZPDHXFCSA-N
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HU-336 is a strongly antiangiogenic compound, significantly inhibiting angiogenesis at concentrations as low as 300 nM. It inhibits angiogenesis by directly inducing apoptosis of vascular endothelial cells without changing the expression of pro- and antiangiogenic cytokines and their receptors. HU-336 is highly effective against tumor xenografts in nude mice.^[1]

See also

• HU-210
• HU-331
• HU-345

References

1. Natalya M. Kogan; et al. (2006). "A Cannabinoid Quinone Inhibits Angiogenesis by Targeting Vascular Endothelial Cells". Molecular Pharmacology. 70 (1): 51–59. doi:10.1124/mol.105.021089. PMID 16571653.