Cyclic nucleotide-gated channel alpha 1

CNGA1
Identifiers
Aliases	CNGA1, CNCG, CNCG1, CNG-1, CNG1, RCNC1, RCNCa, RCNCalpha, RP49, Cyclic nucleotide-gated channel alpha 1, cyclic nucleotide gated channel alpha 1
External IDs	MGI: 88436 HomoloGene: 55432 GeneCards: CNGA1
Genetically Related Diseases
retinitis pigmentosa[1]
Targeted by Drug
guanosine cyclic 3',5'-phosphate[2]
Gene ontology Molecular function • intracellular cGMP activated cation channel activity • nucleotide binding • intracellular cyclic nucleotide activated cation channel activity • cGMP binding • ion channel activity • intracellular cAMP activated cation channel activity • protein binding • voltage-gated potassium channel activity Cellular component • integral component of membrane • membrane • plasma membrane • photoreceptor outer segment • integral component of plasma membrane • photoreceptor outer segment membrane Biological process • response to stimulus • regulation of rhodopsin mediated signaling pathway • regulation of membrane potential • ion transport • cation transmembrane transport • transmembrane transport • transport • visual perception • rhodopsin mediated signaling pathway • potassium ion transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1259	12788
Ensembl	ENSG00000198515	ENSMUSG00000067220
UniProt	P29973	P29974
RefSeq (mRNA)	NM_000087 NM_001142564	NM_007723
RefSeq (protein)	NP_000078.2 NP_001136036.1 NP_000078.2	NP_031749.2
Location (UCSC)	Chr 4: 47.94 – 48.02 Mb	Chr 5: 72.6 – 72.64 Mb
PubMed search	[3]	[4]
Wikidata

View/Edit Human

View/Edit Mouse

Cyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein.^[5]

See also

• Cyclic nucleotide-gated ion channel

References

1. "Diseases that are genetically associated with CNGA1 view/edit references on wikidata".
2. "Drugs that physically interact with cGMP-gated cation channel alpha-1 view/edit references on wikidata".
3. "Human PubMed Reference:".
4. "Mouse PubMed Reference:".
5. "Entrez Gene: CNGA1 cyclic nucleotide gated channel alpha 1". Ncbi.nlm.nih.gov. Retrieved 2016-08-02.

Further reading

• Hofmann F, Biel M, Kaupp UB (December 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacological Reviews. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102.
• Pittler SJ, Lee AK, Altherr MR, Howard TA, Seldin MF, Hurwitz RL, Wasmuth JJ, Baehr W (March 1992). "Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel". The Journal of Biological Chemistry. 267 (9): 6257–62. PMID 1372902.
• Arsenault TV, Sauder DN, Harley CB, McKenzie RC (March 1992). "Identification and characterization of a partial cDNA expressing interleukin-1-like activity in keratinocytes". Molecular Immunology. 29 (3): 431–8. doi:10.1016/0161-5890(92)90031-R. PMID 1372959.
• Dhallan RS, Macke JP, Eddy RL, Shows TB, Reed RR, Yau KW, Nathans J (August 1992). "Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression". The Journal of Neuroscience. 12 (8): 3248–56. PMID 1379636.
• Dryja TP, Finn JT, Peng YW, McGee TL, Berson EL, Yau KW (October 1995). "Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa". Proceedings of the National Academy of Sciences of the United States of America. 92 (22): 10177–81. Bibcode:1995PNAS...9210177D. doi:10.1073/pnas.92.22.10177. PMC 40759. PMID 7479749.
• Distler M, Biel M, Flockerzi V, Hofmann F (November 1994). "Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells". Neuropharmacology. 33 (11): 1275–82. doi:10.1016/0028-3908(94)90027-2. PMID 7532814.
• Griffin CA, Ding CL, Jabs EW, Hawkins AL, Li X, Levine MA (April 1993). "Human rod cGMP-gated cation channel gene maps to 4p12-->centromere by chromosomal in situ hybridization". Genomics. 16 (1): 302–3. doi:10.1006/geno.1993.1187. PMID 7683629.
• Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Paloma E, Martínez-Mir A, García-Sandoval B, Ayuso C, Vilageliu L, Gonzàlez-Duarte R, Balcells S (October 2002). "Novel homozygous mutation in the alpha subunit of the rod cGMP gated channel (CNGA1) in two Spanish sibs affected with autosomal recessive retinitis pigmentosa". Journal of Medical Genetics. 39 (10): E66. doi:10.1136/jmg.39.10.e66. PMC 1734976. PMID 12362048.
• Cheng CH, Yew DT, Kwan HY, Zhou Q, Huang Y, Liu Y, Chan WY, Yao X (October 2002). "An endogenous RNA transcript antisense to CNG(alpha)1 cation channel mRNA". Molecular Biology of the Cell. 13 (10): 3696–705. doi:10.1091/mbc.E02-03-0127. PMC 129976. PMID 12388767.
• Zhong H, Molday LL, Molday RS, Yau KW (November 2002). "The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry". Nature. 420 (6912): 193–8. Bibcode:2002Natur.420..193Z. doi:10.1038/nature01201. PMC 2877395. PMID 12432397.
• Zheng J, Trudeau MC, Zagotta WN (December 2002). "Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit". Neuron. 36 (5): 891–6. doi:10.1016/S0896-6273(02)01099-1. PMID 12467592.
• Kang K, Bauer PJ, Kinjo TG, Szerencsei RT, Bönigk W, Winkfein RJ, Schnetkamp PP (April 2003). "Assembly of retinal rod or cone Na(+)/Ca(2+)-K(+) exchanger oligomers with cGMP-gated channel subunits as probed with heterologously expressed cDNAs". Biochemistry. 42 (15): 4593–600. doi:10.1021/bi027276z. PMID 12693957.
• Zhang Q, Zulfiqar F, Riazuddin SA, Xiao X, Ahmad Z, Riazuddin S, Hejtmancik JF (November 2004). "Autosomal recessive retinitis pigmentosa in a Pakistani family mapped to CNGA1 with identification of a novel mutation". Molecular Vision. 10: 884–9. PMID 15570217.
• Shi F, Perez E, Wang T, Peitz B, Lapolt PS (2005). "Stage- and cell-specific expression of soluble guanylyl cyclase alpha and beta subunits, cGMP-dependent protein kinase I alpha and beta, and cyclic nucleotide-gated channel subunit 1 in the rat testis". Journal of Andrology. 26 (2): 258–63. PMID 15713832.

External links

• GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview
• CNGA1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.