Estrogen-related receptor beta

ESRRB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases ESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2, estrogen related receptor beta
External IDs MGI: 1346832 HomoloGene: 69108 GeneCards: ESRRB
Targeted by Drug
biochanin a, daidzein, genistein, diethylstilbestrol[1]
Orthologs
Species Human Mouse
Entrez

2103

26380

Ensembl

ENSG00000119715

ENSMUSG00000021255

UniProt

O95718

Q61539

RefSeq (mRNA)

NM_004452

NM_001159500
NM_011934

RefSeq (protein)

NP_004443.3

NP_001152972.1
NP_036064.3

Location (UCSC) Chr 14: 76.31 – 76.5 Mb Chr 12: 86.36 – 86.52 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

Estrogen-related receptor beta (ERR-β), also known as NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (EStrogen Related Receptor Beta) gene .[4]

Function

This gene encodes a protein with sequence similarity to the estrogen receptor, a member of nuclear hormone receptor family of steroid hormone receptors. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development.[4]

References

  1. ↑ "Drugs that physically interact with Steroid hormone receptor ERR2 view/edit references on wikidata".
  2. ↑ "Human PubMed Reference:".
  3. ↑ "Mouse PubMed Reference:".
  4. 1 2 "Entrez Gene: ESRRB estrogen-related receptor beta".

Further reading

  • Giguère V, Yang N, Segui P, Evans RM (Jan 1988). "Identification of a new class of steroid hormone receptors". Nature. 331 (6151): 91–4. doi:10.1038/331091a0. PMID 3267207. 
  • Sladek R, Beatty B, Squire J, Copeland NG, Gilbert DJ, Jenkins NA, Giguère V (Oct 1997). "Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene". Genomics. 45 (2): 320–6. doi:10.1006/geno.1997.4939. PMID 9344655. 
  • Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, Nordenskjöld M, Gustafsson JA (Dec 1997). "Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern". The Journal of Clinical Endocrinology and Metabolism. 82 (12): 4258–65. doi:10.1210/jc.82.12.4258. PMID 9398750. 
  • Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q, Caskey CT (Mar 1999). "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR". Gene. 228 (1-2): 101–9. doi:10.1016/S0378-1119(98)00619-2. PMID 10072763. 
  • Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM (Dec 1999). "Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2". Molecular Endocrinology. 13 (12): 2151–62. doi:10.1210/me.13.12.2151. PMID 10598588. 
  • Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE (Apr 2003). "Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition". Journal of Molecular Biology. 327 (4): 819–32. doi:10.1016/S0022-2836(03)00183-9. PMID 12654265. 
  • Kruijver FP, Balesar R, Espila AM, Unmehopa UA, Swaab DF (Nov 2003). "Estrogen-receptor-beta distribution in the human hypothalamus: similarities and differences with ER alpha distribution". The Journal of Comparative Neurology. 466 (2): 251–77. doi:10.1002/cne.10899. PMID 14528452. 
  • Stossi F, Barnett DH, Frasor J, Komm B, Lyttle CR, Katzenellenbogen BS (Jul 2004). "Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors". Endocrinology. 145 (7): 3473–86. doi:10.1210/en.2003-1682. PMID 15033914. 
  • Verdier-Sevrain S, Yaar M, Cantatore J, Traish A, Gilchrest BA (Aug 2004). "Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism". FASEB Journal. 18 (11): 1252–4. doi:10.1096/fj.03-1088fje. PMID 15208259. 
  • Smith LH, Coats SR, Qin H, Petrie MS, Covington JW, Su M, Eren M, Vaughan DE (Aug 2004). "Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells". Circulation Research. 95 (3): 269–75. doi:10.1161/01.RES.0000136521.70093.f1. PMID 15217907. 
  • Liu PY, Christian RC, Ruan M, Miller VM, Fitzpatrick LA (Feb 2005). "Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease". The Journal of Clinical Endocrinology and Metabolism. 90 (2): 1041–6. doi:10.1210/jc.2004-1211. PMID 15536156. 
  • Cheung CP, Yu S, Wong KB, Chan LW, Lai FM, Wang X, Suetsugi M, Chen S, Chan FL (Mar 2005). "Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues". The Journal of Clinical Endocrinology and Metabolism. 90 (3): 1830–44. doi:10.1210/jc.2004-1421. PMID 15598686. 
  • Zhou W, Liu Z, Wu J, Liu JH, Hyder SM, Antoniou E, Lubahn DB (Feb 2006). "Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta". The Journal of Clinical Endocrinology and Metabolism. 91 (2): 569–79. doi:10.1210/jc.2004-1957. PMID 16332939. 

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