FOXP4

FOXP4
Identifiers
Aliases	FOXP4, hFKHLA, forkhead box P4
External IDs	MGI: 1921373 HomoloGene: 12536 GeneCards: FOXP4
Genetically Related Diseases
prostate cancer[1]
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding • DNA binding • protein binding • metal ion binding Cellular component • nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116113	74123
Ensembl	ENSG00000137166	ENSMUSG00000023991
UniProt	Q8IVH2	Q9DBY0
RefSeq (mRNA)	NM_001012426 NM_001012427 NM_138457	NM_001110824 NM_001110825 NM_028767
RefSeq (protein)	NP_001012426.1 NP_001012427.1 NP_612466.1	NP_001104294.1 NP_001104295.1 NP_083043.2
Location (UCSC)	Chr 6: 41.55 – 41.6 Mb	Chr 17: 47.87 – 47.92 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Forkhead box protein P4 is a protein that in humans is encoded by the FOXP4 gene.^[4]

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.^[4]

References

1. "Diseases that are genetically associated with FOXP4 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. "Entrez Gene: FOXP4 forkhead box P4".

Further reading

• Katoh M, Katoh M (2005). "Human FOX gene family (Review)". Int. J. Oncol. 25 (5): 1495–500. doi:10.3892/ijo.25.5.1495. PMID 15492844.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lu MM, Li S, Yang H, Morrisey EE (2003). "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues". Gene Expr. Patterns. 2 (3–4): 223–8. doi:10.1016/S1567-133X(02)00058-3. PMID 12617805.
• Teufel A, Wong EA, Mukhopadhyay M, et al. (2003). "FoxP4, a novel forkhead transcription factor". Biochim. Biophys. Acta. 1627 (2–3): 147–52. doi:10.1016/S0167-4781(03)00074-5. PMID 12818433.
• Lu MM, Li S, Yang H, Morrisey EE (2002). "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues". Mech. Dev. 119 Suppl 1: S197–202. doi:10.1016/S0925-4773(03)00116-3. PMID 14516685.
• Li S, Weidenfeld J, Morrisey EE (2004). "Transcriptional and DNA Binding Activity of the Foxp1/2/4 Family Is Modulated by Heterotypic and Homotypic Protein Interactions". Mol. Cell. Biol. 24 (2): 809–22. doi:10.1128/MCB.24.2.809-822.2004. PMC 343786. PMID 14701752.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hannenhalli S, Putt ME, Gilmore JM, et al. (2006). "Transcriptional genomics associates FOX transcription factors with human heart failure". Circulation. 114 (12): 1269–76. doi:10.1161/CIRCULATIONAHA.106.632430. PMID 16952980.