ZBTB7B

ZBTB7B
Identifiers
Aliases	ZBTB7B, THPOK, ZBTB15, ZFP-67, ZFP67, ZNF857B, c-KROX, hcKROX, CKROX, zinc finger and BTB domain containing 7B
External IDs	MGI: 102755 HomoloGene: 7605 GeneCards: ZBTB7B
Gene ontology Molecular function • DNA binding • protein binding • metal ion binding • nucleic acid binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • protein homodimerization activity Cellular component • nucleus • nucleoplasm Biological process • multicellular organism development • ectoderm development • cell differentiation • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of gene expression • regulation of CD4-positive, alpha-beta T cell differentiation • regulation of CD8-positive, alpha-beta T cell differentiation • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51043	22724
Ensembl	ENSG00000160685	ENSMUSG00000028042
UniProt	O15156	Q64321
RefSeq (mRNA)	NM_001252406 NM_001256455	NM_009565
RefSeq (protein)	NP_001239335.1 NP_001243384.1	NP_033591.2
Location (UCSC)	Chr 1: 155 – 155.02 Mb	Chr 3: 89.38 – 89.39 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ZBTB7B gene.^[3][4][5] ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes (e.g. COL1A1; MIM 120150) and has a role in development.[supplied by OMIM]^[5]

See also

• Zbtb7

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Widom RL, Culic I, Lee JY, Korn JH (Dec 1997). "Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression". Gene. 198 (1–2): 407–20. doi:10.1016/S0378-1119(97)00360-0. PMID 9370309.
4. Galera P, Musso M, Ducy P, Karsenty G (Oct 1994). "c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin". Proc Natl Acad Sci U S A. 91 (20): 9372–6. doi:10.1073/pnas.91.20.9372. PMC 44814. PMID 7937772.
5. "Entrez Gene: ZBTB7B zinc finger and BTB domain containing 7B".

Further reading

• Heegaard AM, Gehron Robey P, Vogel W, et al. (1998). "Functional characterization of the human biglycan 5'-flanking DNA and binding of the transcription factor c-Krox". J. Bone Miner. Res. 12 (12): 2050–60. doi:10.1359/jbmr.1997.12.12.2050. PMID 9421237.
• Ghayor C, Herrouin JF, Chadjichristos C, et al. (2000). "Regulation of human COL2A1 gene expression in chondrocytes. Identification of C-Krox-responsive elements and modulation by phenotype alteration". J. Biol. Chem. 275 (35): 27421–38. doi:10.1074/jbc.M002139200. PMID 10856292.
• Widom RL, Lee JY, Joseph C, et al. (2002). "The hcKrox gene family regulates multiple extracellular matrix genes". Matrix Biol. 20 (7): 451–62. doi:10.1016/S0945-053X(01)00167-6. PMID 11691585.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Kypriotou M, Beauchef G, Chadjichristos C, et al. (2007). "Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors". J. Biol. Chem. 282 (44): 32000–14. doi:10.1074/jbc.M705197200. PMID 17698844.

External links

• ZBTB7B protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.