OR1A1

OR1A1
Identifiers
Aliases	OR1A1, OR17-7, olfactory receptor family 1 subfamily A member 1
External IDs	MGI: 1333770 HomoloGene: 8219 GeneCards: OR1A1
Gene ontology Molecular function • signal transducer activity • olfactory receptor activity • G-protein coupled receptor activity Cellular component • plasma membrane • membrane • integral component of membrane Biological process • sensory perception of smell • G-protein coupled receptor signaling pathway • signal transduction • response to stimulus • detection of chemical stimulus involved in sensory perception of smell Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8383	258706
Ensembl	ENSG00000172146	ENSMUSG00000070377
UniProt	Q9P1Q5	n/a
RefSeq (mRNA)	NM_014565	NM_146711
RefSeq (protein)	NP_055380.2	n/a
Location (UCSC)	Chr 17: 3.22 – 3.22 Mb	Chr 11: 74.21 – 74.21 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Olfactory receptor 1A1 is a protein that in humans is encoded by the OR1A1 gene.^[3][4]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[4]

See also

• Olfactory receptor

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D (Apr 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334.
4. "Entrez Gene: OR1A1 olfactory receptor, family 1, subfamily A, member 1".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes.". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR1A1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.