ID4

ID4
Identifiers
Aliases	ID4, IDB4, bHLHb27, inhibitor of DNA binding 4, HLH protein
External IDs	MGI: 99414 HomoloGene: 1186 GeneCards: ID4
Gene ontology Molecular function • protein dimerization activity • transcription corepressor activity • RNA polymerase II transcription factor binding • protein binding Cellular component • cytoplasm • nucleus Biological process • prostate gland stromal morphogenesis • negative regulation of fat cell differentiation • negative regulation of astrocyte differentiation • regulation of transcription, DNA-templated • negative regulation of neuron differentiation • central nervous system myelination • regulation of transcription from RNA polymerase II promoter • G1/S transition of mitotic cell cycle • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • seminal vesicle morphogenesis • cellular protein localization • brain development • positive regulation of gene expression • positive regulation of osteoblast differentiation • prostate gland epithelium morphogenesis • negative regulation of oligodendrocyte differentiation • circadian rhythm • positive regulation of cell proliferation • prostate gland morphogenesis • neuroblast proliferation • cerebral cortex neuron differentiation • cell proliferation • negative regulation of transcription, DNA-templated • hippocampus development • fat cell differentiation • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3400	15904
Ensembl	ENSG00000172201	ENSMUSG00000021379
UniProt	P47928	P41139
RefSeq (mRNA)	NM_001546	NM_031166
RefSeq (protein)	NP_001537.1	NP_112443.1
Location (UCSC)	Chr 6: 19.84 – 19.84 Mb	Chr 13: 48.26 – 48.26 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

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DNA-binding protein inhibitor ID-4 is a protein that in humans is encoded by the ID4 gene.^[3][4]

Function

Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative (antimorph) HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins.^[4]

See also

• Inhibitor of DNA-binding protein

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Pagliuca A, Bartoli PC, Saccone S, Della Valle G, Lania L (Oct 1995). "Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22". Genomics. 27 (1): 200–3. doi:10.1006/geno.1995.1026. PMID 7665172.
4. "Entrez Gene: ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein".

Further reading

• Loveys DA, Streiff MB, Kato GJ (1996). "E2A basic helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein". Nucleic Acids Res. 24 (14): 2813–20. doi:10.1093/nar/24.14.2813. PMC 145994. PMID 8759016.
• Stewart HJ, Zoidl G, Rossner M, Brennan A, Zoidl C, Nave KA, Mirsky R, Jessen KR (1998). "Helix-loop-helix proteins in Schwann cells: a study of regulation and subcellular localization of Ids, REB, and E12/47 during embryonic and postnatal development". J. Neurosci. Res. 50 (5): 684–701. doi:10.1002/(SICI)1097-4547(19971201)50:5<684::AID-JNR6>3.0.CO;2-D. PMID 9418957.
• Rigolet M, Rich T, Gross-Morand MS, Molina-Gomes D, Viegas-Pequignot E, Junien C (1999). "cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene". DNA Res. 5 (5): 309–13. doi:10.1093/dnares/5.5.309. PMID 9872455.
• Beger C, Pierce LN, Kruger M, Marcusson EG, Robbins JM, Welcsh P, Welch PJ, Welte K, King MC, Barber JR, Wong-Staal F (2001). "Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach". Proc. Natl. Acad. Sci. U.S.A. 98 (1): 130–5. doi:10.1073/pnas.98.1.130. PMC 14556. PMID 11136250.
• Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H (2002). "Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation". J. Biol. Chem. 277 (11): 9118–26. doi:10.1074/jbc.M107713200. PMID 11756408.
• Bellido M, Aventín A, Lasa A, Estivill C, Carnicer MJ, Pons C, Matías-Guiu X, Bordes R, Baiget M, Sierra J, Nomdedéu JF (2004). "Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia". Haematologica. 88 (9): 994–1001. PMID 12969807.
• Chan AS, Tsui WY, Chen X, Chu KM, Chan TL, Chan AS, Li R, So S, Yuen ST, Leung SY (2003). "Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma". Oncogene. 22 (44): 6946–53. doi:10.1038/sj.onc.1206799. PMID 14534543.
• Shan L, Yu M, Qiu C, Snyderwine EG (2004). "Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas". Am. J. Pathol. 163 (6): 2495–502. doi:10.1016/S0002-9440(10)63604-8. PMC 1892385. PMID 14633621.
• Umetani N, Takeuchi H, Fujimoto A, Shinozaki M, Bilchik AJ, Hoon DS (2005). "Epigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosis". Clin. Cancer Res. 10 (22): 7475–83. doi:10.1158/1078-0432.CCR-04-0689. PMID 15569977.
• Yu L, Liu C, Vandeusen J, Becknell B, Dai Z, Wu YZ, Raval A, Liu TH, Ding W, Mao C, Liu S, Smith LT, Lee S, Rassenti L, Marcucci G, Byrd J, Caligiuri MA, Plass C (2005). "Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia". Nat. Genet. 37 (3): 265–74. doi:10.1038/ng1521. PMID 15723065.
• Wu Q, Hoffmann MJ, Hartmann FH, Schulz WA (2006). "Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer". Mol. Cancer. 4 (1): 16. doi:10.1186/1476-4598-4-16. PMC 1131921. PMID 15876350.
• Peddada S, Yasui DH, LaSalle JM (2006). "Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome". Hum. Mol. Genet. 15 (12): 2003–14. doi:10.1093/hmg/ddl124. PMC 1931415. PMID 16682435.
• Hagiwara K, Nagai H, Li Y, Ohashi H, Hotta T, Saito H (2007). "Frequent DNA methylation but not mutation of the ID4 gene in malignant lymphoma". Journal of Clinical and Experimental Hematopathology. 47 (1): 15–8. doi:10.3960/jslrt.47.15. PMID 17510533.
• Noetzel E, Veeck J, Niederacher D, Galm O, Horn F, Hartmann A, Knüchel R, Dahl E (2008). "Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer". BMC Cancer. R8: 154. doi:10.1186/1471-2407-8-154. PMC 2435120. PMID 18513385.

External links

• ID4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.