Biphenylindanone A

Biphenylindanone A

Clinical data
ATC code	none
Identifiers
IUPAC name 3’-(((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro- 1H-inden-5-yl)oxy)methyl)biphenyl-4-carboxylic acid
PubChem (CID)	9868580
IUPHAR/BPS	3954
ChemSpider	8044271
ChEMBL	CHEMBL593013
Chemical and physical data
Formula	C30H30O4
Molar mass	454.556 g/mol
3D model (Jmol)	Interactive image
SMILES c3cc(C(O)=O)ccc3-c(ccc4)cc4COc(c1C)cc(c(C2=O)c1C)CC2C5CCCC5
InChI InChI=1S/C30H30O4/c1-18-19(2)28-25(15-26(29(28)31)22-7-3-4-8-22)16-27(18)34-17-20-6-5-9-24(14-20)21-10-12-23(13-11-21)30(32)33/h5-6,9-14,16,22,26H,3-4,7-8,15,17H2,1-2H3,(H,32,33) Key:KMKBEESNZAPKMP-UHFFFAOYSA-N
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Biphenylindanone A (BINA, LS-193,571) is a research agent which acts as a potent and selective positive allosteric modulator for the group II metabotropic glutamate receptor subtype mGluR2.

In animal studies it showed anxiolytic and antipsychotic effects,^[1] and blocked the effects produced by the hallucinogenic drug DOB. BINA and other selective mGluR2 positive modulators have therefore been suggested as a novel class of drugs for the treatment of schizophrenia which may have superior properties to traditional antipsychotic drugs.^[2]

BINA decreases cocaine self-administration in rats, with no effect on food self-administration, and is in regard to this discrimination superior to the mGluR_2/3 agonist LY-379,268^[3]

References

1. Galici R; Jones CK; Hemstapat K; et al. (2006). "Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice". The Journal of Pharmacology and Experimental Therapeutics. 318 (1): 173–85. doi:10.1124/jpet.106.102046. PMID 16608916.
2. Benneyworth MA, Xiang Z, Smith RL, Garcia EE, Conn PJ, Sanders-Bush E (2007). "A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis". Molecular Pharmacology. 72 (2): 477–84. doi:10.1124/mol.107.035170. PMID 17526600.
3. Jin, Xinchun; Semenova, Svetlana; Yang, Li; Ardecky, Robert; Sheffler, Douglas J; Dahl, Russell; Conn, P Jeffrey; Cosford, Nicholas DP; Markou, Athina (2010). "The mGluR2 Positive Allosteric Modulator BINA Decreases Cocaine Self-Administration and Cue-Induced Cocaine-Seeking and Counteracts Cocaine-Induced Enhancement of Brain Reward Function in Rats". Neuropsychopharmacology. 35 (10): 2021–36. doi:10.1038/npp.2010.82. PMC 2922422. PMID 20555310.