Sabeluzole

Sabeluzole

Clinical data
ATC code	none
Legal status
Legal status	Unscheduled
Identifiers
IUPAC name 1-[4-[1,3-benzothiazol-2-yl(methyl)amino]piperidin-1-yl]-3-(4-fluorophenoxy)propan-2-ol
CAS Number	104383-17-7
PubChem (CID)	59823
ChemSpider	53964
UNII	A998504XY4
Chemical and physical data
Formula	C22H26FN3O2S
Molar mass	415.524 g/mol
3D model (Jmol)	Interactive image
SMILES CN(C1CCN(CC1)CC(COC2=CC=C(C=C2)F)O)C3=NC4=CC=CC=C4S3
InChI InChI=1S/C22H26FN3O2S/c1-25(22-24-20-4-2-3-5-21(20)29-22)17-10-12-26(13-11-17)14-18(27)15-28-19-8-6-16(23)7-9-19/h2-9,17-18,27H,10-15H2,1H3 Key:IGMKTIJBFUMVIN-UHFFFAOYSA-N
(verify)

Sabeluzole (R-58,735) is a nootropic and neuroprotective drug which was originally developed for the treatment of Alzheimer's disease,^[1][2] and has subsequently been researched for other applications such as sleep apnoea.^[3] It acts primarily as an NMDA antagonist,^[4] but other mechanisms of action may also be important.^[5][6]

See also

• Memantine

References

1. Clincke GH; Tritsmans L; Idzikowski C; Amery WK; Janssen PA (1988). "The effect of R 58 735 (Sabeluzole) on memory functions in healthy elderly volunteers". Psychopharmacology. 94 (1): 52–7. doi:10.1007/BF00735880. PMID 3126527.
2. Mohr E; Nair NP; Sampson M; Murtha S; Belanger G; Pappas B; Mendis T (August 1997). "Treatment of Alzheimer's disease with sabeluzole: functional and structural correlates". Clinical Neuropharmacology. 20 (4): 338–45. doi:10.1097/00002826-199708000-00005. PMID 9260731.
3. Hedner J; Grunstein R; Eriksson B; Ejnell H (May 1996). "A double-blind, randomized trial of sabeluzole--a putative glutamate antagonist--in obstructive sleep apnea". Sleep. 19 (4): 287–9. PMID 8776785.
4. Van der Valk JB; Vijverberg HP (February 1993). "Chronic sabeluzole treatment of cultured rat cerebellar granule cells reduces N-methyl-D-aspartate-induced inward current". European Journal of Pharmacology. 232 (1): 131–4. doi:10.1016/0014-2999(93)90738-4. PMID 8458392.
5. Geerts H; Nuydens R; De Jong M; Cornelissen F; Nuyens R; Wouters L (1996). "Sabeluzole stabilizes the neuronal cytoskeleton". Neurobiology of Aging. 17 (4): 573–81. doi:10.1016/0197-4580(96)00067-x. PMID 8832632.
6. Uberti D; Rizzini C; Galli P; Pizzi M; Grilli M; Lesage A; Spano P; Memo M (June 1997). "Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death". Synapse (New York, N.Y.). 26 (2): 95–103. doi:10.1002/(SICI)1098-2396(199706)26:2<95::AID-SYN1>3.0.CO;2-8. PMID 9131769.