CBiPES

CBiPES

Clinical data
ATC code	none
Identifiers
IUPAC name N-(4'-cyano-[1,1'-biphenyl]-3-yl-N-(3-pyridinylmethyl)ethanesulfonamide
CAS Number	856702-40-4
PubChem (CID)	9864510
IUPHAR/BPS	3372
ChemSpider	8040202
Chemical and physical data
Formula	C21H19N3O2S
Molar mass	377.459 g/mol
3D model (Jmol)	Interactive image
SMILES N#Cc1ccc(cc1)-c(ccc2)cc2N(S(=O)(=O)CC)Cc3cccnc3
InChI InChI=1S/C21H19N3O2S/c1-2-27(25,26)24(16-18-5-4-12-23-15-18)21-7-3-6-20(13-21)19-10-8-17(14-22)9-11-19/h3-13,15H,2,16H2,1H3 Key:HDVYXILCBYGKGU-UHFFFAOYSA-N

CBiPES is a drug used in scientific research that acts as a selective positive allosteric modulator for the metabotropic glutamate receptor group II subtype mGluR₂. It has potentially antipsychotic effects in animal models, and is used for researching the role of mGluR₂ receptors in schizophrenia and related disorders.^[1][2][3]

References

1. Johnson, M. P.; Barda, D.; Britton, T. C.; Emkey, R.; Hornback, W. J.; Jagdmann, G. E.; McKinzie, D. L.; Nisenbaum, E. S.; Tizzano, J. P.; Schoepp, D. D. (2005). "Metabotropic glutamate 2 receptor potentiators: Receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)". Psychopharmacology. 179 (1): 271–283. doi:10.1007/s00213-004-2099-9. PMID 15717213.
2. Fell, M. J.; Katner, J. S.; Johnson, B. G.; Khilevich, A.; Schkeryantz, J. M.; Perry, K. W.; Svensson, K. A. (2010). "Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge". Neuropharmacology. 58 (3): 632–639. doi:10.1016/j.neuropharm.2009.11.014. PMID 19951716.
3. Sanger, H.; Hanna, L.; Colvin, E. M.; Grubisha, O.; Ursu, D.; Heinz, B. A.; Findlay, J. D.; Vivier, R. G.; Sher, E.; Lodge, D.; Monn, J. A.; Broad, L. M. (2012). "Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR". Neuropharmacology. 66: 264–273. doi:10.1016/j.neuropharm.2012.05.023. PMID 22659090.